p75NTR (D4B3) XP? Rabbit mAb

• 产品编号：CST-8238S      品牌：CST       原厂货号：8238S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

p75NTR (D4B3) XP® Rabbit mAb 兔单抗识别内源性的总p75NTR蛋白。该单克隆抗体由合成的人类p75NTR蛋白Arg198位点附近肽段免疫动物而制成。P75神经营养素受体（p75NTR），是肿瘤坏死因子受体超家族的成员，由多个富含半胱氨酸的配体结合域、一个跨膜序列和一个非催化细胞质域构成（1）。p75NTR在单独或与其他受体蛋白相互作用时会显示看起来矛盾的功能。p75NTR与Trk受体协同，识别神经营养因子和传递到细胞内的生长信号。激活PI3K-AKT信号需要p75NTR和TrkA，而TrkA可以单独激活MAP激酶通路。相反，p75NTR可能通过JNK，确保受伤的神经元和错付发育的新生儿神经元发生适当的凋亡（2）。？p75NTR蛋白的序列剪切与APP和Notch比较相似。首先，α-分泌酶移除p75NTR胞内段，消除配体介导的信号。与此同时，膜锚定的剪切产物可以继续微调Trk介导的营养过程。γ-分泌酶剪切跨膜结构域，从锚定的膜上释放胞质内尾段，允许其胞内段转移至细胞核中（3,4）。

1. Chao, M.V. (2003) Nat. Rev. Neurosci. 4, 299-309.
2. Nykjaer, A. et al. (2005) Curr. Opin. Neurobiol. 15, 49-57.
3. Kanning, K.C. et al. (2003) J. Neurosci. 23, 5425-5436.
4. Jung, K.M. et al. (2003) J. Biol. Chem. 278, 42161-42169.

原厂资料：

Specificity / Sensitivity

p75NTR (D4B3) XP® Rabbit mAb recognizes endogenous levels of total p75NTR protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg198 of human p75NTR protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg198 of human p75NTR protein.

1. Chao, M.V. (2003) Nat. Rev. Neurosci. 4, 299-309.
2. Nykjaer, A. et al. (2005) Curr. Opin. Neurobiol. 15, 49-57.
3. Kanning, K.C. et al. (2003) J. Neurosci. 23, 5425-5436.
4. Jung, K.M. et al. (2003) J. Biol. Chem. 278, 42161-42169.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody.