CDC73 (D38E12) Rabbit mAb

• 产品编号：CST-8126S      品牌：CST       原厂货号：8126S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

CDC73 (D38E12) Rabbit mAb能够检测内源性CDC73总蛋白。该单克隆抗体是由合成的人源的针对CDC73蛋白Arg407处肽段免疫动物而生产的。CDC73 (HPRT2)是一个公认的肿瘤抑制蛋白，它通过与RNA聚合酶II结合抑制细胞周期进程（1,2）。CDC73通常被称为甲状旁腺功能亢进蛋白，它在内分泌器官中表达，如肾脏、心脏和骨骼肌，分布于核内及胞浆（3）。CDC73与β-catenin的羧基末端区域结合，是Wnt信号通路的调节子(4)。编码CDC73蛋白的基因突变后，可以引起内分泌疾病即甲状旁腺功能亢进症2，表现为高钙血症，骨吸收和颌骨肿瘤的发展(5)。

1. Rozenblatt-Rosen, O. et al. (2005) Mol Cell Biol 25, 612-20.
2. Shi, X. et al. (1997) Mol Cell Biol 17, 1160-9.
3. Woodard, G.E. et al. (2005) Oncogene 24, 1272-6.
4. Mosimann, C. et al. (2006) Cell 125, 327-41.
5. Bradley, K.J. et al. (2006) Clin Endocrinol (Oxf) 64, 299-306.

原厂资料：

Homology

Species predicted to react based on 100% sequence homology: Mouse

Specificity / Sensitivity

CDC73 (D38E12) Rabbit mAb recognizes endogenous levels of total CDC73 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg407 of human CDC73 protein. 

Background

CDC73 (HPRT2) is a putative tumor suppressor protein thought to bind RNA polymerase II to help inhibit cell cycle progression (1,2). Commonly referred to as parafibromin, CDC73 is expressed in endocrine tissues, kidney, heart, and skeletal muscle and is localized to both nuclear and cytoplasmic compartments (3). CDC73 acts as a Wnt signaling regulator as it binds the carboxy-terminal region of β-catenin (4). Mutations in the corresponding gene cause an endocrine disorder known as hyperparathyroidism 2, which is characterized by hypercalcemia, bone resorption, and the development of jaw tumors (5).

1. Rozenblatt-Rosen, O. et al. (2005) Mol Cell Biol 25, 612-20.
2. Shi, X. et al. (1997) Mol Cell Biol 17, 1160-9.
3. Woodard, G.E. et al. (2005) Oncogene 24, 1272-6.
4. Mosimann, C. et al. (2006) Cell 125, 327-41.
5. Bradley, K.J. et al. (2006) Clin Endocrinol (Oxf) 64, 299-306.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody