MAML2 (D41E6) Rabbit mAb

• 产品编号：CST-6988S      品牌：CST       原厂货号：6988S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

MAML2 (D41E6) Rabbit mAb兔单抗可以识别内源性的总MAML2蛋白。合成与人源MAML2蛋白 Asp800邻近的氨基酸残基序列一致的肽段，免疫动物获得单克隆抗体。Mastermind-like (MAML)家族蛋白是果蝇Mastermind蛋白的同源物。在哺乳动物中这一家族包括有三个成员：MAML1, MAML2, and MAML3 (1,2)。MAML复合物与Notch的细胞内结构域（ICN）和转录因子CSL(RBP-Jκ)一起调控Notch靶基因的表达（3-5）。MAML1也可以与MEF2C（肌细胞增强因子2C）结合调控肌生成（6）。在患有粘液表皮样癌和Warthin 瘤的病人体内，往往可以发现MAML2与粘液表皮样癌转位基因（MECT1，也称为WAMTP1 或TORC1）融合（7）。

1. Wu, L. et al. (2002) Mol. Cell Biol. 22, 7688-7700.
2. Lin, S.E. et al. (2002) J. Biol. Chem. 277, 50612-50620.
3. Kitagawa, M. et al. (2001) Mol. Cell Biol. 21, 4337-4346.
4. Nam, Y. et al. (2003) J. Biol. Chem. 278, 21232-21239.
5. Nam, Y. et al. (2006) Cell 124, 973-983.
6. Shen, H. et al. (2006) Genes Dev. 20, 675-688.
7. Tonon, G. et al. (2003) Nat. Genet. 33, 208-213.

原厂资料：

Specificity / Sensitivity

MAML2 (D41E6) Rabbit mAb detects endogenous levels of total MAML2 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp800 of human MAML2 protein.

Background

Mastermind-like (MAML) family of proteins are homologs of Drosophila Mastermind. The family is composed of three members in mammals: MAML1, MAML2, and MAML3 (1,2). MAML complexes with the intracellular domain of Notch (ICN) and the transcription factor CSL (RBP-Jκ) to regulate Notch target gene expression (3-5). MAML1 also interacts with MEF2C (myocyte enhancer factor 2C) to regulate myogenesis (6). MAML2 is frequently found to be fused with Mucoepidermoid carcinoma translocated gene 1 (MECT1, also know as WAMTP1 or TORC1) in patients with mucoepidermoid carcinomas and Warthin''s tumors (7).

1. Wu, L. et al. (2002) Mol. Cell Biol. 22, 7688-7700.
2. Lin, S.E. et al. (2002) J. Biol. Chem. 277, 50612-50620.
3. Kitagawa, M. et al. (2001) Mol. Cell Biol. 21, 4337-4346.
4. Nam, Y. et al. (2003) J. Biol. Chem. 278, 21232-21239.
5. Nam, Y. et al. (2006) Cell 124, 973-983.
6. Shen, H. et al. (2006) Genes Dev. 20, 675-688.
7. Tonon, G. et al. (2003) Nat. Genet. 33, 208-213.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody.