LATS2 (D83D6) Rabbit mAb

• 产品编号：CST-5888S      品牌：CST       原厂货号：5888S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

LATS2 (D83D6) Rabbit mAb 能够检测转染的LATS2总蛋白。该单克隆抗体是有合成的人源的针对LATS2蛋白氨基末端的肽段免疫动物生产的。LATS2是属于NDR激酶家族的一种AGC激酶。它是LATS家族的一种肿瘤抑制基因，在中心体复制、有丝分裂保真度维持和基因组稳定性中发挥重要作用(1)。LATS2通过下调周期蛋白E/CDK2激酶活性来抑制G1/S转化时的细胞生长(2)。它也可以调节Hippo通路，该通路能够调节细胞增殖和促进凋亡从而控制器官大小和肿瘤的进程(3,4,5)。

1. Yabuta, N. et al. (2007) J Biol Chem 282, 19259-71.
2. Li, Y. et al. (2003) Oncogene 22, 4398-405.
3. Harvey, K. and Tapon, N. (2007) Nat Rev Cancer 7, 182-91.
4. Zeng, Q. and Hong, W. (2008) Cancer Cell 13, 188-92.
5. Visser, S. and Yang, X. (2010) Cell Cycle 9, 3892-903.

原厂资料：

Homology

Species predicted to react based on 100% sequence homology: Monkey

Specificity / Sensitivity

LATS2 (D83D6) Rabbit mAb detects transfected levels of total LATS2 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human LATS2 protein. 

Background

LATS2 is an AGC kinase of the NDR family of kinases. It is a tumor suppressor of the LATS family, and plays a critical role in centrosome duplication, maintenance of mitotic fidelity, and genomic stability (1). LATS2 inhibits cell growth at the G1/S transition by down-regulating cyclin E/CDK2 kinase activity (2). It also plays an important role in regulation of the Hippo pathway, a pathway that is important in controlling organ size and tumor progression by regulating cellular proliferation and promoting apoptosis (3,4,5)

1. Yabuta, N. et al. (2007) J Biol Chem 282, 19259-71.
2. Li, Y. et al. (2003) Oncogene 22, 4398-405.
3. Harvey, K. and Tapon, N. (2007) Nat Rev Cancer 7, 182-91.
4. Zeng, Q. and Hong, W. (2008) Cancer Cell 13, 188-92.
5. Visser, S. and Yang, X. (2010) Cell Cycle 9, 3892-903.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody.