IGBP1 (5F6) Mouse mAb

• 产品编号：CST-5699S      品牌：CST       原厂货号：5699S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

IGBP1 (5F6) Mouse mAb能够检测内源IGBP1蛋白总体水平。此 单克隆抗体是通过合成人源对应的IGBP1融合蛋白来免疫动物而获得。免疫球蛋白结合蛋白1(IGBP1)与丝氨酸/苏氨酸磷酸酶PP2A调控亚单元C相互作用,也能够与其它蛋白磷酸酶PP4和PP6交叉反应 (1-3)。IGBP1结合到 PP2A上，对PP2A催化活性和底物的特异性有调控作用(1-4)。最近的研究证据表明，IGBP1可能在PP2Ac泛素化过程中通过与E3泛素连接酶MID1相作用而发挥作用(5,6)。IGBP1通过促进PP2A活性，抑制细胞因子引起的p38有丝分裂激活蛋白激酶活性而负调控凋亡(7)。与BCR交叉连接后, IGBP1与酪氨酸磷酸化分子短暂的相互作用并诱导了下游信号的转导(7)。有证据表明IGBP1与PP2A的相互作用可能参与到了雷帕霉素敏感的mTOR信号通路(8,9)。IGBP1和MID形成复合体被鉴定为X连锁的Optiz GBBB 综合征发病机理中的决定条件(10)。

原厂资料：

Specificity / Sensitivity

IGBP1 (5F6) Mouse mAb recognizes endogenous levels of total IGBP1 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a recombinant protein specific to human IGBP1.

Background

Immunoglobulin binding protein 1 (IGBP1) interacts with the regulatory subunit C of serine/threonine phosphatase PP2A, and other protein phosphotases, PP4 and PP6 (1-3). Binding of IGBP1 to PP2A has been shown to regulate PP2A catalytic activity and its substrate specificity (1-4). Recent evidence suggests that IGBP1 may play a role in PP2Ac ubiquitination via its association with E3 ubiquitin ligase MID1 (5,6). IGBP1 negatively regulates apoptosis by targeting PP2A activity to suppress p38 mitogen-activated protein kinase activation by cytokines (7). Upon BCR cross-linking, IGBP1 transiently associates with tyrosine phosphorylated molecules, which in turn induce downstream signal transduction (7). Evidence suggests that IGBP1 association with PP2A may be involved in the rapamycin sensitive mTOR pathway (8,9). Formation of the IGBP1 and Midline ring finger protein (MID) complex has been identified as a prerequisite to pathogenesis of X-linked Optiz GBBB syndrome (10).

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody.