PPP2R4 (5G3) Mouse mAb

产品编号：CST-5686S 品牌：CST 原厂货号：5686S
产品分类：抗体 > 一抗 > 蛋白特异性一抗
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包装：

运保温度:

–20°C.

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描述：

PPP2R4 (5G3) Mouse mAb能够识别内源性PPP2R4蛋白。该抗体不与其他PP2A蛋白发生交叉反应。该单克隆抗体是由重组的鼠源的PPP2R4特异性蛋白免疫动物生产的。丝氨酸/苏氨酸蛋白磷酸酶2A调节亚基4(PPP2R4)是PP2A调节亚基B的一个组分(1)。PPP2R4被认为是磷酸酶激活剂(PTPA)并且具有肽酰脯氨酰异构酶活性(2-3)。PPIases催化多肽链上脯氨酸残基肽键的顺式异构化，这导致蛋白质的快速折叠(2)。PPP2R4的ATP酶活性对于PP2A的phosphotyrosyl磷酸酶活性是必须的(2-4)。有证据表明PPP2R4诱导凋亡不依赖于经典的PP2A调节通路(4)。

原厂资料：

Specificity / Sensitivity

PPP2R4 (5G3) Mouse mAb recognizes endogenous levels of total PPP2R4 protein. This antibody does not cross-react with other PP2A proteins.

Source / Purification

Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the mouse PPP2R4 protein.

Background

Serine/threonine protein phosphatase 2A regulatory subunit 4 (PPP2R4) is one of the constituents of the regulatory subunit B' of PP2A (1). PPP2R4 is also known as the phosphatase activator (PTPA) and known to have the peptidyl prolyl isomerase (PPIase) activity (2-3). PPIases catalyze cis-trans isomerization of peptide bonds of proline residues in the polypeptide chain; this leads to the rapid folding of proteins (2). The ATPase activity of PPP2R4 is required for the phosphotyrosyl phosphatase activity of PP2A (2-4). Evidence suggests that PPP2R4 induces apoptosis independent of the canonical PP2A-mediated pathways (4).

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody.