RAIG1 Antibody

• 产品编号：CST-5657S      品牌：CST       原厂货号：5657S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

RAIG1抗体识别内源性的RAIG1总蛋白。多克隆抗体是通过一种合成的肽段去免疫动物产生。这种合成的肽段与邻近人源RAIG1蛋白的Val295氨基酸残基序列一致。抗体由蛋白A和肽段亲和层析技术纯化得到.维甲酸诱导基因1(RAIG1)，也称RAI3 或 GPRC5A，属于G蛋白偶联受体家族(GPCRs)，GPCRs是哺乳动物体内最丰富的受体家族，由超过一千个成员组成[1]。维甲酸(RA)是一组多效信号分子，调节广泛的生理发育过程。至今认为RAIG1可能是RA信号通路下游靶标[2]。RAIF1在肺组织和一些肺癌细胞系中表达，编码七种跨膜糖蛋白，被认为是肺癌抑制基因[3,4].

1. Jörissen, H. et al. (2009) BMC Cancer 9, 200.
2. Xu, J. et al. (2005) Am J Respir Cell Mol Biol 32, 381-7.
3. Veling, G. et al. (1992) Kinderkrankenschwester 11, 118-20.
4. Ye, X. et al. (2009) Cancer Biol Ther 8, 951-62.

原厂资料：

Specificity / Sensitivity

RAIG1 Antibody recognizes endogenous levels of total RAIG1 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val295 of human RAIG1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

Retinoic Acid-Induced Gene 1 (RAIG1), also called RAI3 and GPRC5A, belongs to the family of G protein-coupled receptors (GPCRs). GPCRs are the largest and most abundant receptor family in mammals, composed of more than one thousand members (1). Retinoic Acids (RA) are a group of pleiotropic signaling molecules that regulate a broad range of physiologic and developmental processes. It is thought that RAIG1 may be a downstream target of RA signaling (2). RAIG1 is expressed in lung tissue and in several lung cancer cell lines, and encodes a seven-transmembrane glycoprotein presumed to be a lung tumor suppressor gene (3,4).

1. Jörissen, H. et al. (2009) BMC Cancer 9, 200.
2. Xu, J. et al. (2005) Am J Respir Cell Mol Biol 32, 381-7.
3. Veling, G. et al. (1992) Kinderkrankenschwester 11, 118-20.
4. Ye, X. et al. (2009) Cancer Biol Ther 8, 951-62.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM
NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C.
Do not aliquot the antibody.