Msx1 (P5) Antibody

• 产品编号：CST-5378S      品牌：CST       原厂货号：5378S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

Msx1 (P5)抗体识别内源性的总Msx1蛋白。合成与人源Msx1蛋白的邻近Pro5氨基酸残基序列一致的肽段，免疫动物获得多克隆抗体。抗体通过蛋白A和肽亲和层析纯化。Msh同源异型框1蛋白(Msx1)是肌节同源异型框(Msh)基因家族的成员，在在胚胎发育过程的转录抑制因子，并在四肢形成、颅面发育、牙齿发育中起重要作用（1-3）。Msh1在发育中的甲床间质中（2），胎儿毛囊泡，表皮成纤维细胞中表达。在成人上皮来源的组织中减弱表达（4）Msx1与Wnt1调控网络协同建立了中脑多巴胺能祖细胞结构域，这一区域产生神经元，对正常大脑功能有关键作用，并且在帕金森病中也会改变这些细胞(5)。相应Msx1基因突变与牙齿异常生长的威特科普综合征有关（6）。其他的Msx1的遗传突变会导致 Witkop综合症（牙齿指甲综合征），还有牙齿异常生长的非综合性唇腭裂(2,7).

1. Jezewski, P.A. et al. (2003) J Med Genet 40, 399-407.
2. Jumlongras, D. et al. (2001) Am J Hum Genet 69, 67-74.
3. Lidral, A.C. and Reising, B.C. (2002) J Dent Res 81, 274-8.
4. Stelnicki, E.J. et al. (1997) Differentiation 62, 33-41.
5. Andersson, E. et al. (2006) Cell 124, 393-405.
6. Nieminen, P. et al. (2003) J Dent Res 82, 1013-7.
7. van den Boogaard, M.J. et al. (2000) Nat Genet 24, 342-3.

原厂资料：

Homology

Species predicted to react based on 100% sequence homology: Monkey

Specificity / Sensitivity

Msx1 (P5) Antibody detects endogenous levels of total Msx1 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to amino acid sequences surrounding Pro5 of human Msx1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

Msh homeobox 1 (Msx1) is a Muscle Segment Homeobox (Msh) gene family member that acts as a transcriptional repressor during embryonic development, playing an important role in limb pattern formation, craniofacial development, and tooth development (1-3). Msx1 is expressed in the mesenchyme of the developing nail bed (2) and in fetal hair follicles, epidermis and fibroblasts; reduced expression is seen in adult epithelial-derived tissues (4). Msx1 acts in concert with the Wnt1 network to establish the midbrain dopaminergic progenator domain, a region that gives rise to neurons that are critical for normal brain function and are the cells affected in Parkinson disease (5). Mutation in the corresponding Msx1 gene correlates with abnormal tooth development in patients diagnosed with Wolf-Hirschhorn syndrome (6). Other genetic changes in the Msx1 gene result in Witkop Syndrome ("tooth and nail syndrome") and cases of abnormal tooth development associated with non-syndromic orofacial clefting (2,7).

1. Jezewski, P.A. et al. (2003) J Med Genet 40, 399-407.
2. Jumlongras, D. et al. (2001) Am J Hum Genet 69, 67-74.
3. Lidral, A.C. and Reising, B.C. (2002) J Dent Res 81, 274-8.
4. Stelnicki, E.J. et al. (1997) Differentiation 62, 33-41.
5. Andersson, E. et al. (2006) Cell 124, 393-405.
6. Nieminen, P. et al. (2003) J Dent Res 82, 1013-7.
7. van den Boogaard, M.J. et al. (2000) Nat Genet 24, 342-3.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM
NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C.
Do not aliquot the antibody.