FoxP2 (D55H9) Rabbit mAb

• 产品编号：CST-5337S      品牌：CST       原厂货号：5337S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

FoxP2 (D55H9)Rabbit mAb 兔单抗识别内源性的总FoxP2蛋白。合成与人源FoxP2蛋白的邻近Leu623氨基酸残基序列一致的肽段，免疫动物获得单克隆抗体。叉头盒蛋白（Fox）是一组进化中较保守的转录因子，它们拥有一个翼状的螺旋DNA结合结构域而被称为叉头盒（1）。人体内，有超过43种不同亚型的Fox蛋白。FoxP亚家族有4个成员FoxP1到FoxP4，它们表达广泛，并且在器官发育，免疫反应和癌症病理等过程中扮演重要角色（2-4）。FoxP亚家族有几个不同于其他Fox蛋白的特征：它们的叉头盒位于羧基端，它们包含有促进同源和异源二聚化的基序。FoxP蛋白通常作为转录抑制因子（4,5）。FoxP2调控肺和神经系统发育（6-10）。FoxP2发生包括点突变，截断，缺失和染色体易位在内的突变都与遗传性的演讲和语言障碍有关（11,12）。

1. Myatt, S.S. and Lam, E.W. (2007) Nat Rev Cancer 7, 847-59.
2. Shu, W. et al. (2001) J Biol Chem 276, 27488-97.
3. Lu, M.M. et al. (2002) Gene Expr Patterns 2, 223-8.
4. Koon, H.B. et al. (2007) Expert Opin Ther Targets 11, 955-65.
5. Li, S. et al. (2004) Mol Cell Biol 24, 809-22.
6. Shu, W. et al. (2007) Development 134, 1991-2000.
7. Yang, Z. et al. (2010) Life Sci 87, 17-25.
8. Konopka, G. et al. (2009) Nature 462, 213-7.
9. Enard, W. et al. (2009) Cell 137, 961-71.
10. Morikawa, Y. et al. (2009) Neuroscience 162, 1150-62.
11. Scharff, C. and White, S.A. (2004) Ann N Y Acad Sci 1016, 325-47.
12. Fisher, S.E. and Scharff, C. (2009) Trends Genet 25, 166-77.

原厂资料：

Homology

Species predicted to react based on 100% sequence homology: Mouse, Rat

Specificity / Sensitivity

FoxP2 (D55H9) Rabbit mAb detects endogenous levels of total FoxP2 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu623 of human FoxP2 protein.

Background

Forkhead box (Fox) proteins are a family of evolutionarily conserved transcription factors containing a sequence known as Forkhead box or winged helix DNA binding domain (1). The human genome contains 43 Fox proteins that are divided into subfamilies. The FoxP subfamily has four members, FoxP1 to FoxP4, which are broadly expressed and play important roles in organ development, immune response, and cancer pathogenesis (2-4). The FoxP subfamily has several characteristics that are atypical among Fox proteins: their Forkhead domain is located at the carboxy-terminal region, and they contain motifs that promote homo- and heterodimerization. FoxP proteins usually function as transcriptional repressors (4,5).FoxP2 regulates lung and nerve system development (6-10). Mutations, including point mutation, truncation, deletion, and chromosomal translocation, involving FoxP2 are associated with an inherited form of speech and language disorder (11,12).

1. Myatt, S.S. and Lam, E.W. (2007) Nat Rev Cancer 7, 847-59.
2. Shu, W. et al. (2001) J Biol Chem 276, 27488-97.
3. Lu, M.M. et al. (2002) Gene Expr Patterns 2, 223-8.
4. Koon, H.B. et al. (2007) Expert Opin Ther Targets 11, 955-65.
5. Li, S. et al. (2004) Mol Cell Biol 24, 809-22.
6. Shu, W. et al. (2007) Development 134, 1991-2000.
7. Yang, Z. et al. (2010) Life Sci 87, 17-25.
8. Konopka, G. et al. (2009) Nature 462, 213-7.
9. Enard, W. et al. (2009) Cell 137, 961-71.
10. Morikawa, Y. et al. (2009) Neuroscience 162, 1150-62.
11. Scharff, C. and White, S.A. (2004) Ann N Y Acad Sci 1016, 325-47.
12. Fisher, S.E. and Scharff, C. (2009) Trends Genet 25, 166-77.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody