Androgen Receptor (D6F11) XP? Rabbit mAb

• 产品编号：CST-5153P      品牌：Cell Signaling Technology       原厂货号：5153P
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

Androgen Receptor (D6F11) XP® Rabbit mAb能够检测内源性水平的总雄激素受体蛋白。该单克隆抗体是由对应人雄激素受体蛋白氨基末端区域的重组蛋白免疫动物而生产的。雄激素受体（AR）是锌指转录因子，属于核受体超家族，通过磷酸化和配体结合的二聚化被激活（1）。这促进了细胞核定位和雄激素靶基因中雄激素与应答元件的结合。 AR在男性发育和前列腺癌发展的几个阶段起着至关重要的作用（2,3）。

1. Li, J. and Al-Azzawi, F. (2009) Maturitas 63, 142-8.
2. Avila, D.M. et al. (2001) J. Steroid. Biochem. Mol. Biol. 76, 135-142.
3. Montgomery, J.S. et al. (2001) J. Pathol. 195, 138-146.

原厂资料：

Specificity / Sensitivity

Androgen Receptor (D6F11) XP® Rabbit mAb detects endogenous levels of total androgen receptor protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with recombinant protein corresponding to residues near the amino terminal region of human androgen receptor protein.

Background

Androgen receptor (AR), a zinc finger transcription factor belonging to the nuclear receptor superfamily, is activated by phosphorylation and dimerization upon ligand binding (1). This promotes nuclear localization and binding of AR to androgen response elements in androgen target genes. AR plays a crucial role in several stages of male development and the progression of prostate cancer (2,3).

1. Li, J. and Al-Azzawi, F. (2009) Maturitas 63, 142-8.
2. Avila, D.M. et al. (2001) J. Steroid. Biochem. Mol. Biol. 76, 135-142.
3. Montgomery, J.S. et al. (2001) J. Pathol. 195, 138-146.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody.