SRF (D71A9) XP? Rabbit mAb

产品编号：CST-5147P 品牌：Cell Signaling Technology 原厂货号：5147P
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

40 ul

运保温度:

–20°C

到货周期：

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描述：

SRF (D71A9) XP® Rabbit mAb兔单抗能检测内源性总SRF蛋白水平。该单克隆抗体通过使用与人源SRF蛋白丝氨酸（375位点）周围残基的合成肽段免疫动物而获得。血清效应因子(SRF) 是67 kDa的磷酸化蛋白，它与辅助因子一起修饰即时早期基因的转录，这些基因的启动子中包含血清效应元件(1,2)。SRF包含一些磷酸化位点(3)，但是磷酸化的功能性序列目前还不明确。一些生长因子和钙调节激酶，如p90RSK、CaM kinase IV，能磷酸化SRF蛋白的丝氨酸103位点(4,5)，SRF蛋白的丝氨酸103位点是MAPKAP激酶2的细胞核上靶点(6)。

原厂资料：

Specificity / Sensitivity

SRF (D71A9) XP® Rabbit mAb recognizes endogenous levels of total SRF protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser375 of human SRF protein.

Background

The serum response factor (SRF) is a 67 kDa phospho-protein that, together with auxiliary factors, modulates transcription of immediate early genes containing serum response elements at their promoters (1,2). SRF contains several phosphorylation sites (3), but functional consequences of phosphorylation have not been identified unequivocally. Several growth factor- and calcium-regulated kinases, such as p90RSK and CaM kinase IV, can phosphorylate SRF at Ser103 (4,5), and Ser103 of SRF is also a nuclear target for MAPKAP kinase 2 (6).

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody