RecQL1 (Q1N3) Mouse mAb

产品编号：CST-4839S 品牌：CST 原厂货号：4839S
产品分类：抗体 > 一抗 > 蛋白特异性一抗
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包装：

运保温度:

–20°C

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描述：

RecQL1 (Q1N3) Mouse mAb 能够检测内源性RecQL1总蛋白水平。该单克隆抗体是用人的RecQL1蛋白免疫动物生产的。 RecQ家族是一组DNA解旋酶，在整体基因组稳定性过程中发挥着重要作用(1)。五个已知的RecQ蛋白中的三个(BLM，WRN和RECQL4)发生突变会引起临床上不同的功能紊乱如早衰和癌症易感性(2,3)。与这些突变点相关疾病的不同临床表型表明该解旋酶家族的成员在DNA代谢中具有特殊的作用。RecQL1是RecQ家族丰度最高的蛋白，也是第一个被发现的家族成员。与RecQL1相关的疾病未见报道，而且其生物学活性尚未研究充分(4)。最近研究发现RecQL1的缺失负面影响基因组的维持和细胞增殖，表明了其在DNA损伤修复和细胞周期进程中的作用(5,6)。有报道指出细胞中RecQL1连同其它RecQ家族成员的上调能够应答致癌病毒性感染(7)。

原厂资料：

Specificity / Sensitivity

RecQL1 (Q1N3) Mouse mAb detects endogenous levels of total RecQL1 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with human RecQL1 recombinant protein.

Background

The RecQ family is a group of DNA helicases that play an important role in global genomic stability (1). Mutations in three of the five known human RecQ proteins (BLM, WRN and RECQL4) give rise to clinically distinct disorders that are characterized by features such as premature aging and predisposition to cancer (2,3). The clinical distinction of each disease associated with these mutations points to distinct roles that members of this helicase family play in DNA metabolism. RecQL1 is the most abundant protein of the RecQ family and was the first family member to be discovered. No disease associations have been reported with RecQL1 and its biological activities are not well understood (4). It has recently been shown that depletion of RecQL1 negatively affects genomic maintenance and cellular proliferation – which may point to a role in DNA damage repair and cell cycle progression (5,6). Upregulation of RecQL1 along with other RecQ family members has been reported in cells in response to oncogenic viral infection (7).

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody.