HER4/ErbB4 (111B2) Rabbit mAb

• 产品编号：CST-4795S      品牌：CST       原厂货号：4795S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

HER4/ErbB4 (111B2)兔单抗能检测到内源ErbB4蛋白的表达。本抗体不与其它ErbB家族的蛋白发生交叉反应。单克隆抗体通过用多肽免疫动物得到，该多肽是根据人的ErbB4蛋白羧基端序列合成的。研究表明HER/ErbB酪氨酸激酶受体家族在正常发育、心脏功能和肿瘤中发挥作用（1,2）。HER4/ErbB4和家族其它成员一样，有四个胞外功能区，一个跨膜区和一个具有激活酪氨酸激酶活性的胞内区（3）。通过结合神经调节素(NRGs)和/或EGF家族配体，ErbB4形成同源二聚体或与ErbB家族的其它成员形成异二聚体，进而使受体活化进行信号传递（3）。ErbB4普遍高表达于脑和心脏。ErbB4在乳腺癌、小儿脑癌和其它种类肿瘤上的表达和正常组织发育以及肿瘤的发生均有关系（3）。

1. Holbro, T. and Hynes, N.E. (2004) Annu Rev Pharmacol Toxicol 44, 195-217.
2. Roskoski, R. (2004) Biochem Biophys Res Commun 319, 1-11.
3. Carpenter, G. (2003) Exp Cell Res 284, 66-77.

原厂资料：

Homology

Species predicted to react based on 100% sequence homology: Rat

Specificity / Sensitivity

HER4/ErbB4 (111B2) Rabbit mAb detects endogenous levels of ErbB4 protein. This antibody does not cross-react with other ErbB family members.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy-terminus of human ErbB4.

Background

The HER/ErbB receptor tyrosine kinase family has been implicated in normal development, cardiac function and cancer (1,2). HER4/ErbB4, like other family members, has four ectodomains, a single transmembrane domain and a cytoplasmic tail containing the active tyrosine kinase domain (3). By binding to neuregulins and/or EGF family ligands, ErbB4 forms either a homodimer or heterodimer with other ErbB family members, which results in receptor activation and signaling (3). ErbB4 is ubiquitously expressed with the highest expression occurring in brain and heart. The expression of ErbB4 in breast cancer, pediatric brain cancer and other types of carcinomas has been reported suggesting that ErbB4 expression is involved in both normal tissue development and carcinogenesis (3).

1. Holbro, T. and Hynes, N.E. (2004) Annu Rev Pharmacol Toxicol 44, 195-217.
2. Roskoski, R. (2004) Biochem Biophys Res Commun 319, 1-11.
3. Carpenter, G. (2003) Exp Cell Res 284, 66-77.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody