DcR1 Antibody

• 产品编号：CST-4756S      品牌：CST       原厂货号：4756S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

DcR1 Antibody 能够检测内源DcR1总蛋白。肿瘤坏死因子受体家族，包括TNF-RI、FAS、DR3、DR4、DR5和DR6，在各个生理系统细胞凋亡的调控中起着重要的作用（1,2）。受体被一个家族的细胞因子，包括TNF、FasL和TRAIL激活。它们的特点是含有一个高度保守、富含半胱氨酸的重复序列的胞外区和一个胞内保守的约80个氨基酸的死亡结构域（DD）。 DD对于死亡信号转导的传递很重要，它通过招募其他的DD配体蛋白（FADD，TRADD，RIP）到死亡诱导信号复合物（DISC）来发挥作用，进而激活半胱天冬酶蛋白。诱饵受体（DcR1、DcR2和DcR3）家族调控死亡受体信号，其缺乏细胞质DD，并通过竞争配体以抑制死亡受体介导的细胞凋亡（3-5）。诱饵受体的表达对于调节某些类型的癌症的细胞凋亡提供了一种机制，这有助于开展化疗敏感性研究（6-8）。

1. Nagata, S. (1997) Cell 88, 355-365.
2. Thorburn, A. (2004) Cell. Signal. 16, 139-144.
3. Sheridan, J.P. et al. (1997) Science 277, 818-821.
4. Marsters, S.A. et al. (1997) Curr. Biol. 7, 1003-1006.
5. Pitti, R.M. et al. (1998) Nature 396, 699-703.
6. Liu, X. et al. (2005) Cancer Res. 65, 9169-9175.
7. Spalding, A.C. et al. (2002) Oncogene 21, 260-271.
8. Bernard, D. et al. (2001) J. Biol. Chem. 276, 27322-27328.

原厂资料：

Specificity / Sensitivity

DcR1 Antibody detects endogenous levels of total DcR1 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human DcR1. Antibodies are purified by protein A and peptide affinity chromatography.

Background

The tumor necrosis factor receptor family, which includes TNF-RI, Fas, DR3, DR4, DR5, and DR6, plays an important role in the regulation of apoptosis in various physiological systems (1,2). The receptors are activated by a family of cytokines that include TNF, FasL, and TRAIL. They are characterized by a highly conserved extracellular region containing cysteine-rich repeats and a conserved intracellular region of about 80 amino acids termed the death domain (DD). The DD is important for transducing the death signal by recruiting other DD containing adaptor proteins (FADD, TRADD, RIP) to the death-inducing signaling complex (DISC), resulting in activation of caspases. Death receptor signaling is also controlled by a family of decoy receptors (DcR1, DcR2 and DcR3) which lack a cytoplasmic DD and inhibit death receptor-mediated apoptosis by competing for ligand (3-5). Expression of decoy receptors provide a mechanism for certain types of cancer to regulate apoptosis and can contribute to chemosensitivity (6-8).

1. Nagata, S. (1997) Cell 88, 355-365.
2. Thorburn, A. (2004) Cell. Signal. 16, 139-144.
3. Sheridan, J.P. et al. (1997) Science 277, 818-821.
4. Marsters, S.A. et al. (1997) Curr. Biol. 7, 1003-1006.
5. Pitti, R.M. et al. (1998) Nature 396, 699-703.
6. Liu, X. et al. (2005) Cancer Res. 65, 9169-9175.
7. Spalding, A.C. et al. (2002) Oncogene 21, 260-271.
8. Bernard, D. et al. (2001) J. Biol. Chem. 276, 27322-27328.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM
NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C.
Do not aliquot the antibody.