SSEA4 (MC813) Mouse mAb

• 产品编号：CST-4755P      品牌：Cell Signaling Technology       原厂货号：4755P
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

SSEA4 (MC813)Mouse mAb小鼠单抗识别内源性的SSEA4抗原蛋白。此单抗由人胚胎癌细胞2102Ep cl.2A6免疫注射动物而产生。SSEA4（时期特异性胚胎抗原4）是在人畸胎癌干细胞、人胚胎生殖细胞和人胚胎干细胞表面表达的一类糖脂碳水化合物抗原蛋白（1）。人源SSEA4蛋白在分化的人源胚胎癌细胞表达量下降。SSEA4抗原蛋白在鼠类多潜能细胞种没有表达，但在分化后表达量上升（1,2）。

1. Henderson, J.K. et al. (2002) Stem Cells 20, 329-37.
2. Draper, J.S. et al. (2002) J Anat 200, 249-58.

原厂资料：

Specificity / Sensitivity

SSEA4 (MC813) Mouse mAb detects endogenous levels of SSEA4 antigen.

Source / Purification

Monoclonal antibody is produced by injecting animals with human embryonal carcinoma 2102Ep cl.2A6 cells.

Background

SSEA4 (stage-specific embryonic antigen 4) is a glycolipid carbohydrate epitope expressed on the surface of human teratocarcinoma stem cells, human embryonic germ cells, and human embryonic stem cells (1). Expression of human SSEA4 decreases following differentiation of human embryonal carcinoma cells. Expression of the SSEA4 antigen is absent in murine pluripotent cells, but increases following differentiation (1,2).

1. Henderson, J.K. et al. (2002) Stem Cells 20, 329-37.
2. Draper, J.S. et al. (2002) J Anat 200, 249-58.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody