C-Peptide Antibody

• 产品编号：CST-4593S      品牌：CST       原厂货号：4593S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

C肽抗体用于检测内源性C肽蛋白水平。多克隆抗体通过用对应于人源C肽蛋白序列的合成肽免疫动物制备而得，抗体经蛋白A和肽段亲和层析纯化。糖代谢由激素调节，进食后血糖水平的升高，会通过一种血糖感应的途径来刺激胰岛β细胞分泌胰岛素（1）。前胰岛素，是胰岛素的前体形式，经过加工后形成成熟的胰岛素。胰岛素由A肽和B肽以二硫键相连，而前胰岛素的中部被剪切成C肽，它比胰岛素的半衰期长一些（2）。

1. Straub, S.G. and Sharp, G.W. (2002) Diabetes Metab. Res. Rev. 18, 451-463.
2. Polonsky, K.S. and Rubenstein, A.H. (1984) Diabetes 33, 486-494.

原厂资料：

Specificity / Sensitivity

C-peptide Antibody detects endogenous levels of total C-peptide protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human C-peptide. Antibodies are purified by protein A and peptide affinity chromatography.

Background

Glucose homeostasis is regulated by hormones. Elevation of blood glucose levels during feeding stimulates insulin release from pancreatic β-cells through a glucose sensing pathway (1). Proinsulin, the insulin precursor molecule, is processed prior to its secretion. Insulin is composed of A-peptide and B-peptide which are joined by a disulfide bond. The center one-third of the molecule is cleaved and released as C-peptide, which has a longer half-life than insulin (2).

1. Straub, S.G. and Sharp, G.W. (2002) Diabetes Metab. Res. Rev. 18, 451-463.
2. Polonsky, K.S. and Rubenstein, A.H. (1984) Diabetes 33, 486-494.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM
NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C.
Do not aliquot the antibody