TWEAK Receptor/Fn14 Antibody

• 产品编号：CST-4403S      品牌：CST       原厂货号：4403S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

TWEAK Receptor/Fn14抗体能够检测内源TWEAK蛋白总体水平。此多克隆抗体是通过合成对应的TWEAK Receptor/Fn14 靠近C-末端周围的肽段来免疫动物而获得。抗体是通过protein A和多肽亲和层析纯化。TWEAK的受体,成纤维细胞诱导生长因子14(Fn14), 是TNF受体超家族中的一员，通常参与到细胞生长，粘连和细胞迁移过程中(1)。它的表达受到一系列不同生长因子的调控(1,2)。它的高表达被发现存在一些癌变组织中包括肝癌(3), 胶质母细胞瘤(4)和胰腺癌(5).受体包含了激活NF-κB的TNFR相关因子(TRAF)的结合位点(1,6)。 最近的研究表明在自免疫，癌症中TWEAK和其受体是潜在的治疗靶标(7-9)。

1. Wiley, S.R. et al. (2001) Immunity 15, 837-46.
2. Nakayama, M. et al. (2003) J. Immunol. 170, 341-8.
3. Feng, S.L. et al. (2000) Am. J. Pathol. 156, 1253-61.
4. Tran, N.L. et al. (2003) Am. J. Pathol. 162, 1313-21.
5. Han, H. et al. (2002) Cancer Res. 62, 2890-6.
6. Brown, S.A. et al. (2003) Biochem J. 371, 395-403.
7. Desplat-Jégo, S. et al. (2005) Clin. Immunol. 117, 15-23.
8. Mueller, A.M. et al. (2005) J. Neuroimmunol. 159, 55-65.
9. Winkles, J.A. et al. (2006) Cancer Lett 235, 11-7.

原厂资料：

Specificity / Sensitivity

TWEAK Receptor/Fn14 Antibody detects endogenous levels of total TWEAK Receptor/Fn14 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of the TWEAK Receptor/Fn14. Antibodies were purified by protein A and peptide affinity chromatography.

Background

The receptor for TWEAK, fibroblast growth factor-inducible 14 (Fn14), is a member of the TNF superfamily of receptors thought to be involved in cell growth, adhesion and migration (1). Its expression is regulated by a number of different growth factors (1,2). Elevated expression is also seen in some cancers including hepatocellular carcinomas (3), glioblastomas (4), and pancreatic cancer (5). The receptor contains a binding site for members of the TNFR-associated factor (TRAF) family that promotes the activation of NF-κB (1,6). Recent studies have suggeted some therapeutic potential of TWEAK and its receptor signaling in regards to autoimmunity and cancer treatment (7-9).

1. Wiley, S.R. et al. (2001) Immunity 15, 837-46.
2. Nakayama, M. et al. (2003) J. Immunol. 170, 341-8.
3. Feng, S.L. et al. (2000) Am. J. Pathol. 156, 1253-61.
4. Tran, N.L. et al. (2003) Am. J. Pathol. 162, 1313-21.
5. Han, H. et al. (2002) Cancer Res. 62, 2890-6.
6. Brown, S.A. et al. (2003) Biochem J. 371, 395-403.
7. Desplat-Jégo, S. et al. (2005) Clin. Immunol. 117, 15-23.
8. Mueller, A.M. et al. (2005) J. Neuroimmunol. 159, 55-65.
9. Winkles, J.A. et al. (2006) Cancer Lett 235, 11-7.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM
NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C.
Do not aliquot the antibody.