Dexras1 Antibody

• 产品编号：CST-4229S      品牌：CST       原厂货号：4229S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

Dexras1 Antibody兔多抗能检测内源性总Dexras1蛋白水平。该抗体也能与未知起源的60 kD蛋白发生交叉反应。该多克隆抗体通过使用与人源Dexras1蛋白羧端周围残基相一致的合成磷酸化肽段免疫动物而获得。该抗体经蛋白A和肽亲和层析纯化。Dexras1 (Ras dexamethasone induced 1)属于GRP酶的Ras超家族，初期被鉴定为地塞米松诱导性基因(1,2)。有报道称Dexras1能调节一些特定的信号转导途径，包括MAPK信号转导、NMDA受体氧化一氮调节的信号转导，以及涉及到腺苷酸环化酶的通路(3-5)。Dexras1能直接修饰FE65-APP调节的转录，调节哺乳动物生物钟的感光性(6,7)。

1. Kemppainen, R.J. and Behrend, E.N. (1998) J Biol Chem 273, 3129-31.
2. Tu, Y. and Wu, C. (1999) Biochim Biophys Acta 1489, 452-6.
3. Fang, M. et al. (2000) Neuron 28, 183-93.
4. Graham, T.E. et al. (2004) Biochem Biophys Res Commun 316, 307-12.
5. Nguyen, C.H. and Watts, V.J. (2005) Biochem Biophys Res Commun 332, 913-20.
6. Cheng, H.Y. et al. (2006) J Neurosci 26, 12984-95.
7. Lau, K.F. et al. (2008) J Biol Chem 283, 34728-37.

原厂资料：

Specificity / Sensitivity

Dexras1 Antibody detects endogenous levels of total Dexras1 protein. The antibody also cross-reacts with a 60 kDa protein of unknown origin.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human Dexras1 protein. Antibodies were purified by protein A and peptide affinity chromatography.

Background

Dexras1 (Ras dexamethasone induced 1) belongs to the Ras superfamily of GTPases and was initially identified as a dexamethasone inducible gene (1,2). Dexras1 reportedly regulates several distinct signal transduction pathways, including MAPK signaling, NMDA receptor-nitric oxide-mediated signaling, and pathways involving adenylyl cyclases (3-5). Dexras1 can directly modulate FE65-APP-mediated transcription and regulate the photic sensitivity of the mammalian circadian clock (6,7).

1. Kemppainen, R.J. and Behrend, E.N. (1998) J Biol Chem 273, 3129-31.
2. Tu, Y. and Wu, C. (1999) Biochim Biophys Acta 1489, 452-6.
3. Fang, M. et al. (2000) Neuron 28, 183-93.
4. Graham, T.E. et al. (2004) Biochem Biophys Res Commun 316, 307-12.
5. Nguyen, C.H. and Watts, V.J. (2005) Biochem Biophys Res Commun 332, 913-20.
6. Cheng, H.Y. et al. (2006) J Neurosci 26, 12984-95.
7. Lau, K.F. et al. (2008) J Biol Chem 283, 34728-37.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM
NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C.
Do not aliquot the antibody