EGR1 (15F7) Rabbit mAb

• 产品编号：CST-4153S      品牌：CST       原厂货号：4153S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

EGR1 (15F7)Rabbit mAb识别内源性的总EGR1蛋白。该单克隆抗体由合成的人类EGR1蛋白中氨基末端附近肽段免疫动物而制成。EGR的家庭成员是包含三个重复的锌指DNA结合域的转录因子，它可以EGR响应元素（ER），调节靶基因的表达（1）。EGR家族成员的表达可被生长因子诱导，EGR1的表达可被神经生长因子（NGF）诱导（1,2）。增加EGR1表达可以激活其他信号分子的转录，包括CDK5和酪氨酸羟化酶，对神经细胞生长和分化有长期影响（2,3）。

1. O'Donovan, K.J. et al. (1999) Trends Neurosci. 22, 167-173.
2. Harada, T. et al. (2001) Nat. Cell Biol. 3, 453-459.
3. Papanikolaou, N.A. and Sabban, E.L. (2000) J. Biol. Chem. 275, 26683-26689.

原厂资料：

Homology

Species predicted to react based on 100% sequence homology: Bovine

Specificity / Sensitivity

EGR1 (15F7) Rabbit mAb detects endogenous levels of total EGR1 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the amino terminus of the sequence of human EGR1.

Background

EGR family members are transcriptional factors that contain three repetitive zinc finger DNA binding domains which bind to EGR response elements (ER) to regulate target gene expression (1). The expression of EGR family members is induced by growth factors, with EGR1 expression being induced by NGF (1,2). Increased EGR1 expression activates transcription of other signaling molecules, including CDK5 and tyrosine hydroxylase, and exerts long term effects on neural cell growth and differentiation (2,3).

1. O'Donovan, K.J. et al. (1999) Trends Neurosci. 22, 167-173.
2. Harada, T. et al. (2001) Nat. Cell Biol. 3, 453-459.
3. Papanikolaou, N.A. and Sabban, E.L. (2000) J. Biol. Chem. 275, 26683-26689.

注意事项：

Storage: Storage: Supplied in 10 mM sodium HEPES (pH 7.5),
150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C.