PHF20 (D96F6) XP? Rabbit mAb

• 产品编号：CST-3934S      品牌：CST       原厂货号：3934S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

PHF20 (D96F6) XP® Rabbit mAb兔单抗能够检测内源性PHF20总蛋白水平。通过合成的与人源PHF20蛋白去免疫动物从而制备出此单克隆抗体。PHD finger protein 20 (PHF20)是一个转录因子。PHF20包含一个tudor结构域，这有助于结合到双甲基化的histone H4蛋白Lys20位点(1)。PHF20可能有助于癌症的发展，包括恶性胶质瘤、肺癌、结肠癌和卵巢癌(2-5)。

1. Kim, J. et al. (2006) EMBO Rep 7, 397-403.
2. Fischer, U. et al. (2001) Clin Exp Immunol 126, 206-13.
3. Taniwaki, M. et al. (2006) Int J Oncol 29, 567-75.
4. Bankovic, J. et al. (2009) Lung Cancer 67, 151-9 .
5. Wang, Y. et al. (2002) J Immunol 169, 1102-9.

原厂资料：

Homology

Species predicted to react based on 100% sequence homology: Bovine, Horse

Specificity / Sensitivity

PHF20 (D96F6) XP® Rabbit mAb detects endogenous levels of total PHF20 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the human PHF20 protein.

Background

PHD finger protein 20 (PHF20) is a putative transcription factor protein. PHF20 contains a tudor domain, which facilitates binding to di-methylated histone H4 Lys20 (1). PHF20 may contribute to the development of cancers, including glioblastoma, lung cancer, colon cancer and ovarian cancer (2-5).

1. Kim, J. et al. (2006) EMBO Rep 7, 397-403.
2. Fischer, U. et al. (2001) Clin Exp Immunol 126, 206-13.
3. Taniwaki, M. et al. (2006) Int J Oncol 29, 567-75.
4. Bankovic, J. et al. (2009) Lung Cancer 67, 151-9 .
5. Wang, Y. et al. (2002) J Immunol 169, 1102-9.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody.