Forskolin

• 产品编号：CST-3828S      品牌：CST       原厂货号：3828S
• 产品分类：生化试剂 > 生物试剂 > 生物活性小分子 > 激活剂
• 应用分类：

描述：

Forskolin在二甲基亚砜和甲醇中可溶。DMSO溶液可在-20℃避光保存至少六个月。Forskolin是从印度植物毛喉鞘蕊花中自然产生的二萜类物质，可激活腺苷酸环化酶，从而增加细胞内cAMP浓度（1）。第二信使环磷酸腺苷（cAMP）在哺乳动物细胞中激活cAMP依赖的蛋白激酶（PKA或者cAPK），控制如基因转录、离子转运和蛋白磷酸化等许多细胞内机制（2）。使用HPLC和TLC确定其纯度大于99%。

1. Laurenza, A. et al. (1989) Trends Pharmacol Sci 10, 442-7.
2. Montminy, M. (1997) Annu Rev Biochem 66, 807-22.

原厂资料：

Directions for Use

Forskolin is soluble in DMSO and methanol. DMSO solutions can be stored at -20ºC in the dark for at least six months.

Background

Forskolin, a naturally occurring diterpene from the Indian plant, Coleus forskohlii, activates adenylate cyclase, and thus increases the intracellular cAMP concentration (1). The second messenger cAMP activates cAMP-dependent protein kinase (PKA or cAPK) and controls many cellular mechanisms such as gene transcription, ion transport and protein phosphorylation (2).Purity is greater than 99% as determined by HPLC and TLC.

1. Laurenza, A. et al. (1989) Trends Pharmacol Sci 10, 442-7.
2. Montminy, M. (1997) Annu Rev Biochem 66, 807-22.

注意事项：

Storage: Store lyophilized or in solution at -20°C, desiccated.
Protect from light. In lyophilized form, the chemical is stable for
24 months. Once in solution, use within 3 months to prevent loss
of potency. Aliquot to avoid multiple freeze/thaw cycles.