CDC73 (A264) Antibody

• 产品编号：CST-3644S      品牌：CST       原厂货号：3644S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

CDC73 (A264) Antibody能够识别内源性CDC73总蛋白。 该多克隆抗体是由合成的人源的针对CDC73蛋白丙氨酸(264位)肽段免疫动物，利用多肽亲和层析方法纯化生产的。CDC73 (HPRT2)是一个公认的肿瘤抑制蛋白，它通过与RNA聚合酶II结合抑制细胞周期进程（1,2）。CDC73通常被称为甲状旁腺功能亢进蛋白，它在内分泌器官中表达，如肾脏、心脏和骨骼肌，分布于核内及胞浆（3）。CDC73与β-catenin的羧基末端区域结合，是Wnt信号通路的调节子(4)。编码CDC73蛋白的基因突变后，可以引起内分泌疾病即甲状旁腺功能亢进症2，表现为高钙血症，骨吸收和颌骨肿瘤的发展(5)。

1. Rozenblatt-Rosen, O. et al. (2005) Mol Cell Biol 25, 612-20.
2. Shi, X. et al. (1997) Mol Cell Biol 17, 1160-9.
3. Woodard, G.E. et al. (2005) Oncogene 24, 1272-6.
4. Mosimann, C. et al. (2006) Cell 125, 327-41.
5. Bradley, K.J. et al. (2006) Clin Endocrinol (Oxf) 64, 299-306.

原厂资料：

Specificity / Sensitivity

CDC73 (A264) Antibody detects endogenous levels of total CDC73 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala264 of human CDC73. Antibodies are purified by peptide affinity chromatography.

Background

CDC73 (HPRT2) is a putative tumor suppressor protein thought to bind RNA polymerase II to help inhibit cell cycle progression (1,2). Commonly referred to as parafibromin, CDC73 is expressed in endocrine tissues, kidney, heart, and skeletal muscle and is localized to both nuclear and cytoplasmic compartments (3). CDC73 acts as a Wnt signaling regulator as it binds the carboxy-terminal region of β-catenin (4). Mutations in the corresponding gene cause an endocrine disorder known as hyperparathyroidism 2, which is characterized by hypercalcemia, bone resorption, and the development of jaw tumors (5).

1. Rozenblatt-Rosen, O. et al. (2005) Mol Cell Biol 25, 612-20.
2. Shi, X. et al. (1997) Mol Cell Biol 17, 1160-9.
3. Woodard, G.E. et al. (2005) Oncogene 24, 1272-6.
4. Mosimann, C. et al. (2006) Cell 125, 327-41.
5. Bradley, K.J. et al. (2006) Clin Endocrinol (Oxf) 64, 299-306.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.