PSD95 (D74D3) XP? Rabbit mAb

• 产品编号：CST-3409P      品牌：Cell Signaling Technology       原厂货号：3409P
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

PSD95 (D74D3) XP® Rabbit mAb 兔单抗识别内源性的PSD95总蛋白。该单克隆抗体由合成的人类PSD95蛋白氨基末端附件肽段免疫动物而制成。突触后密集区蛋白95(Postsynaptic Density protein 95,PSD95) 是一种膜相关鸟苷酸激酶（PSD - MAGUK）蛋白质PSD亚族的成员。该家族成员由三个PDZ结构域后的可变N末端，一个SH3结构域和一个无效的鸟苷酸激酶（GK）结构域组成。PSD95是一种脚手架蛋白，参与突触后密集复合物的装配和功能。（1,2）。PSD95通过间接方式参与AMPA受体在突触的定位，涉及Stargazin和相关的跨膜AMPA受体调节蛋白（TARPS）（3）。PSD95与经验依赖的可塑性有关，在学习中起着不可或缺的作用（4）。PSD95基因突变与自闭症有关（5）。

1. Cao, J. et al. (2005) J. Cell Biol 168, 117-26.
2. Chetkovich, D.M. et al. (2002) J. Neurosci. 22, 6415-25.
3. Cai, C. et al. (2006) J. Biol. Chem. 281, 4267-73.
4. Yao, W.D. et al. (2004) Neuron 41, 625-38.
5. Cline, H. (2005) Curr. Biol. 15, R203-5.

原厂资料：

Specificity / Sensitivity

PSD95 (D74D3) XP® Rabbit mAb detects endogenous levels of total PSD95 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues in the amino-terminal sequence of human PSD95.

Background

Postsynaptic Density protein 95 (PSD95) is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. These family members consist of an amino-terminal variable segment followed by three PDZ domains, a SH3 domain and an inactive guanylate kinase (GK) domain. PSD95 is a scaffolding protein involved in the assembly and function of the postsynaptic density complex (1-2). PSD95 participates in synaptic targeting of AMPA receptors through an indirect manner involving Stargazin and related transmembrane AMPA receptor regulatory proteins (TARPs) (3). It is implicated in experience dependent plasticity and plays an indispensable role in learning (4). Mutations in PSD95 are associated with autism (5).

1. Cao, J. et al. (2005) J. Cell Biol 168, 117-26.
2. Chetkovich, D.M. et al. (2002) J. Neurosci. 22, 6415-25.
3. Cai, C. et al. (2006) J. Biol. Chem. 281, 4267-73.
4. Yao, W.D. et al. (2004) Neuron 41, 625-38.
5. Cline, H. (2005) Curr. Biol. 15, R203-5.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.