MNDA (3C1) Rat mAb

• 产品编号：CST-3329S      品牌：CST       原厂货号：3329S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

MNDA (3C1) Rat mAb 兔单抗能够检测内源水平MNDA总蛋白水平。此单克隆抗体是通过人粒性白血球细胞核提取物免疫动物而获得。骨髓细胞核分化抗原(MNDA )是转录调控因子，并在外周血粒性白细胞和单核细胞中组成型表达， 在一些B 细胞中也有低表达(1,2)。MNDA 是干扰素(IFN)所调控的200个基因家族中的一员，它包含了一个或几个由200个氨基酸残基构成的部分保守的区域，这些保守的区域被认为介导了蛋白-蛋白的相互作用(3)。 MNDA 在细胞凋亡中起了重要的作用，它在骨髓发育不良综合症 (MDS)中的表达是降低的(4)。 MNDA 被提议是节缘区淋巴瘤的标记物(5)。

1. Briggs, R.C. et al. (1994) J Cell Biochem 56, 559-67.
2. Miranda, R.N. et al. (1999) Hum Pathol 30, 1040-9.
3. Landolfo, S. et al. (1998) Biochimie 80, 721-8.
4. Briggs, R.C. et al. (2006) Cancer Res 66, 4645-51.
5. Kanellis, G. et al. (2009) Leukemia 23, 1847-57.

原厂资料：

Specificity / Sensitivity

MNDA (3C1) Rat mAb detects endogenous levels of total MNDA protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with nuclear extract from human granulocytes.

Background

MNDA (myeloid cell nuclear differentiation antigen) is a transcription factor constitutively expressed in peripheral blood granulocytes and monocytes; low expression is also found in a subset of B cells (1,2). MNDA is a member of the interferon (IFN)-regulated 200 family of genes, which contain one or more copies of a partially conserved domain of 200 amino acid residues thought to mediate protein-protein interaction (3). MNDA may play a role in apoptosis and its expression is reduced in myelodysplastic syndromes (MDS) (4). MNDA has been proposed to be a marker for nodal marginal zone lymphoma (5).

1. Briggs, R.C. et al. (1994) J Cell Biochem 56, 559-67.
2. Miranda, R.N. et al. (1999) Hum Pathol 30, 1040-9.
3. Landolfo, S. et al. (1998) Biochimie 80, 721-8.
4. Briggs, R.C. et al. (2006) Cancer Res 66, 4645-51.
5. Kanellis, G. et al. (2009) Leukemia 23, 1847-57.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.