GPX1 (C8C4) Rabbit mAb

• 产品编号：CST-3286S      品牌：CST       原厂货号：3286S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

GPX1 (C8C4) Rabbit mAb用于检测内源性GPX1总蛋白水平。单克隆抗体通过用对应于人源GPX1蛋白序列的合成肽免疫动物制备而得。谷胱苷肽过氧化物酶1（GPX1）是一种位于细胞质的含硒蛋白，它可以将过氧化氢还原为水（1）。GPX1是已发现的五种同工酶中最广泛最普通的酶（2）。 它是细胞抗氧化的主要组分，该蛋白与多种疾病有关，如结肠癌（3），冠心病（4）和胰岛素抵抗（1）。

1. McClung, J.P. et al. (2004) Proc. Natl. Acad. Sci. USA 101, 8852-8857.
2. Hamanishi, T. et al. (2004) Diabetes 53, 2455-2460.
3. Drew, J.E. et al. (2005) FEBS Lett. 579, 6135-6139.
4. Winter, J.P. et al. (2003) Coron. Artery Dis. 14, 149-153.

原厂资料：

Specificity / Sensitivity

GPX1 (C8C4) Rabbit mAb detects endogenous levels of total GPX1 protein.

Source / Purification

GPX1 (C8C4) Rabbit mAb is produced by immunizing rabbits with a synthetic peptide corresponding to the sequence of human GPX1.

Background

Glutathione peroxidase 1 (GPX1) is a cytosolic selenoprotein which reduces hydrogen peroxide to water (1). GPX1 is the most abundant and ubiquitous among the five GPX isoforms identified so far (2). It is an important component in the anti-oxidative defense in cells and is associated with a variety of disease conditions, such as colon cancer (3), coronary artery disease (4) and insulin resistance (1).

1. McClung, J.P. et al. (2004) Proc. Natl. Acad. Sci. USA 101, 8852-8857.
2. Hamanishi, T. et al. (2004) Diabetes 53, 2455-2460.
3. Drew, J.E. et al. (2005) FEBS Lett. 579, 6135-6139.
4. Winter, J.P. et al. (2003) Coron. Artery Dis. 14, 149-153.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody.