AMACR (2A10) Mouse mAb

• 产品编号：CST-3207S      品牌：CST       原厂货号：3207S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

AMACR (2A10) Mouse mAb用于检测内源性AMACR总蛋白水平。单克隆抗体通过用纯化的缩短的重组的人AMACR－HIS融合蛋白免疫动物制备而得α甲酰基辅酶A消旋酶(AMACR)，位于过氧化物酶体和线粒体中，在支链脂肪酸和脂肪酶衍生物的β氧化中发挥作用（1）。AMACR是前列腺癌的一种生物标记（2－4）。AMACR的表达同时也跟其它的一些肿瘤有关，如肝细胞癌（1），非侵入性膀胱癌（5），结直肠癌（6）和胃腺癌（7）。

1. Li, W. et al. (2008) J Exp Clin Cancer Res 27, 2.
2. Rubin, M.A. et al. (2002) JAMA 287, 1662-70.
3. Jiang, Z. et al. (2002) Am J Surg Pathol 26, 1169-74.
4. Jiang, Z. et al. (2001) Am J Surg Pathol 25, 1397-404.
5. Gunia, S. et al. (2008) Virchows Arch 453, 165-70.
6. Marx, A. et al. (2008) Virchows Arch 453, 243-248.
7. Truong, C.D. et al. (2008) Int J Clin Exp Pathol 1, 518-523.

原厂资料：

Specificity / Sensitivity

AMACR (2A10) Mouse mAb detects endogenous levels of total AMACR protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a purified truncated recombinant human AMACR-His fusion protein.

Background

α-methylacyl-CoA racemase (AMACR), an enzyme localized in peroxisomes and mitochondria, is involved in the β-oxidation of branched-chain fatty acids and fatty acid derivatives (1). AMACR has been reported to be a biomarker for prostate cancer (2-4). The expression of AMACR is also related to other types of cancers such as hepatocellular carcinoma (1), noninvasive bladder cancer (5), colorectal cancer (6) and gastric adenocarcinoma (7).

1. Li, W. et al. (2008) J Exp Clin Cancer Res 27, 2.
2. Rubin, M.A. et al. (2002) JAMA 287, 1662-70.
3. Jiang, Z. et al. (2002) Am J Surg Pathol 26, 1169-74.
4. Jiang, Z. et al. (2001) Am J Surg Pathol 25, 1397-404.
5. Gunia, S. et al. (2008) Virchows Arch 453, 165-70.
6. Marx, A. et al. (2008) Virchows Arch 453, 243-248.
7. Truong, C.D. et al. (2008) Int J Clin Exp Pathol 1, 518-523.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.