Insulin (C27C9) Rabbit mAb

• 产品编号：CST-3014S      品牌：CST       原厂货号：3014S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

Insulin (C27C9)兔单克隆抗体识别内源性的胰岛素总蛋白水平。该单克隆抗体用与人类胰岛素蛋白氨基酸序列对应的人工合成肽段免疫动物制成。血糖平衡是一个被激素调节的核心生理过程。摄食后血糖水平升高，刺激胰岛素通过血糖敏感的途径从胰岛β细胞中释放（1）。胰岛素在分泌前先合成为前胰岛素。A和B链通过二硫键结合形成胰岛素，前体分子的中心区域被切除形成C肽。胰岛素刺激葡萄糖从血中被摄取进入骨骼肌和脂肪组织。胰岛素缺乏导致1型糖尿病（2）。

1. Straub, S.G. and Sharp, G.W. (2002) Diabetes Metab. Res. Rev. 18, 451-463.
2. Concannon, P. et al. (1998) Nat. Genet. 19, 292-296.

原厂资料：

Specificity / Sensitivity

Insulin (C27C9) Rabbit mAb detects endogenous levels of total insulin protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the sequence of human insulin.

Background

The maintenance of glucose homeostasis is an essential physiological process that is regulated by hormones. An elevation in blood glucose levels during feeding stimulates insulin release from pancreatic β cells through a glucose sensing pathway (1). Insulin is synthesized as a precursor molecule, proinsulin, which is processed prior to its secretion. A- and B-peptides are joined together by a disulfide bond to form insulin, while the central portion of the precursor molecule is cleaved and released as the C-peptide. Insulin stimulates glucose uptake from blood into the skeletal muscle and adipose tissue. Insulin deficiency leads to type 1 diabetes mellitus (2).

1. Straub, S.G. and Sharp, G.W. (2002) Diabetes Metab. Res. Rev. 18, 451-463.
2. Concannon, P. et al. (1998) Nat. Genet. 19, 292-296.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.