EpCAM (VU1D9) Mouse mAb

• 产品编号：CST-2929S      品牌：CST       原厂货号：2929S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

EpCAM (VU1D9)小鼠单抗检测内源总EpCAM蛋白水平。单抗由NCI-H69小细胞肺癌细胞免疫动物产生。上皮细胞粘附和激活分子（EpCAM/CD326）是一个跨膜糖蛋白，它在大部分上皮细胞的底外侧表面调节Ca2+非依赖的 同嗜性粘附。EpCAM成人鳞状上皮细胞中不表达，但在腺和鳞状细胞癌症中高表达（1）。第一肿瘤相关抗原之一被发现，EpCAM已是上皮和肿瘤组织的一个标志物，因在癌症中高表达，EpCAM已变成了人类固体癌症上皮细胞系的治疗靶标（综述2,3）。

1. Went, P.T. et al. (2004) Hum Pathol 35, 122-8.
2. Baeuerle, P.A. and Gires, O. (2007) Br J Cancer 96, 417-23.
3. Armstrong, A. and Eck, S.L. (2003) Cancer Biol Ther 2, 320-6.

原厂资料：

Specificity / Sensitivity

EpCAM (VU1D9) Mouse mAb detects endogenous levels of total EpCAM protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with NCI-H69 small cell lung carcinoma cells.

Background

Epithelial cell adhesion and activating molecule (EpCAM/CD326) is a transmembrane glycoprotein that mediates Ca2+-independent, homophilic adhesions on the basolateral surface of most epithelial cells. EpCAM is not expressed in adult squamous epithelium, but it is highly expressed in adeno and squamous cell carcinomas (1). One of the first tumor-associated antigens discovered, EpCAM has long been a marker of epithelial and tumor tissue. Because of its high expression in cancer, EpCAM has become a therapeutic target for human solid tumors of epithelial lineage (reviewed in 2,3).

1. Went, P.T. et al. (2004) Hum Pathol 35, 122-8.
2. Baeuerle, P.A. and Gires, O. (2007) Br J Cancer 96, 417-23.
3. Armstrong, A. and Eck, S.L. (2003) Cancer Biol Ther 2, 320-6.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.