MESDC2 (C22F5) Rabbit mAb

• 产品编号：CST-2763S      品牌：CST       原厂货号：2763S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

MESDC2 (C22F5)Rabbit mAb兔单抗识别内源性的总MESDC2 蛋白.此单克隆抗体是合成的人源MESDC2重组蛋白去免疫动物产生.中胚层发育候选基因1(MESDC1)和 2 (MESDC2)由位于小鼠染色体7的中胚层发育缺失间隔而被鉴定（1），MESD在ER中对低密度脂蛋白受体（LDLR）蛋白起分子伴侣作用，特别与Wnt信号通路共受体LRP5 和LPR6相关（2）。MESD对于合适的LRP5 /折叠和到细胞表面成熟是必须的。这对Wnt信号通路起主要作用（3-5）。MESD和LRP5相互作用被LRP5的一个G171V突变阻断，这一突变发现在高密度骨为特点家族性表型的个体中（6）.

1. Wines, M.E. et al. (2001) Genomics 72, 88-98.
2. Hsieh, J.C. et al. (2003) Cell 112, 355-67.
3. Herz, J. and Marschang, P. (2003) Cell 112, 289-92.
4. Li, Y. et al. (2006) FEBS Lett 580, 5423-8.
5. Li, Y. et al. (2005) J Cell Sci 118, 5305-14.
6. Zhang, Y. et al. (2004) Mol Cell Biol 24, 4677-84.

原厂资料：

Specificity / Sensitivity

MESDC2 (C22F5) Rabbit mAb detects endogenous levels of total MESDC2 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a recombinant human MESDC2 protein.

Background

Mesoderm development candidate genes 1 (MESDC1) and 2 (MESDC2) were identified from the mesoderm development (MESD) deletion interval located on mouse chromosome 7 (1). MESD acts as a chaperone for low-density lipoprotein receptor (LDLR) proteins in the ER, and particularly associates with Wnt signaling pathway coreceptors LRP5 and LPR6 (2). MESD is required for proper LRP5/6 folding and maturation to the cell surface, which plays a major role in Wnt signaling (3-5). The interaction between MESD and LRP5 is disrupted by a G171V mutation in LRP5 that is found in individuals with a familial phenotype characterized by high bone mass (6).

1. Wines, M.E. et al. (2001) Genomics 72, 88-98.
2. Hsieh, J.C. et al. (2003) Cell 112, 355-67.
3. Herz, J. and Marschang, P. (2003) Cell 112, 289-92.
4. Li, Y. et al. (2006) FEBS Lett 580, 5423-8.
5. Li, Y. et al. (2005) J Cell Sci 118, 5305-14.
6. Zhang, Y. et al. (2004) Mol Cell Biol 24, 4677-84.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody.