Wnt3a (C64F2) Rabbit mAb

产品编号：CST-2721S 品牌：CST 原厂货号：2721S
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

运保温度:

–20°C.

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描述：

Wnt3a (C64F2)Rabbit mAb兔单抗识别 L细胞和条件培养基中L/Wnt3a细胞转染的Wnt3a 蛋白.单克隆抗体是通过合成肽段去免疫动物产生。这种合成肽段与邻近人Wnt3a蛋白 Leu256氨基酸残基序列一致。Wnt家族包括一些分泌糖蛋白，在动物发育中起重要作用（1）。有19个Wnt基因在人的基因组中编码功能特异的Wnt蛋白（2）。Wnt成员结合Frizzled家族7个跨膜蛋白，激活一些信号通路（3）。经典Wnt/ β-catenin通路需要一个来自低密度脂蛋白受体（LDLR）家族的共受体，如LRP5 和LRP6（4）。异常的Wnt通路激活活化与几种癌症相关（5）。

原厂资料：

Homology

Species predicted to react based on 100% sequence homology: Human, Rat

Specificity / Sensitivity

Wnt3a (C64F2) Rabbit mAb detects transfected Wnt3a protein in L cells and the conditioned medium from L/Wnt3a cells.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu256 of human Wnt3a.

Background

The Wnt family includes several secreted glycoproteins that play important roles in animal development (1). There are 19 Wnt genes in the human genome that encode functionally distinct Wnt proteins (2). Wnt members bind to the Frizzled family of seven-pass transmembrane proteins and activate several signaling pathways (3). The canonical Wnt/β-catenin pathway also requires a coreceptor from the low-density lipoprotein receptor family (4). Aberrant activation of Wnt signaling pathways is involved in several types of cancers (5).

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody