T-Bet/TBX21 (D6N8B) XP? Rabbit mAb (Alexa Fluor? 647 Conjugate)

• 产品编号：CST-14307S      品牌：CST       原厂货号：14307S
• 产品分类：抗体 > 一抗 > 染料标记抗体
• 应用分类：

描述：

Specificity / Sensitivity

T-Bet/TBX21 (D6N8B) XP^® Rabbit mAb (Alexa Fluor ® 647 Conjugate) recognizes endogenous levels of total T-Bet/TBX21 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly465 of human T-bet/TBX21 protein.

Description

This Cell Signaling Technology antibody is conjugated to Alexa Fluor^® 647 fluorescent dye and tested in-house for direct flow cytometry analysis in human cells. The antibody is expected to exhibit the same species cross-reactivity as the unconjugated T-bet/TBX21 (D6N8B) XP^® Rabbit mAb #13232.

原厂资料：

Specificity / Sensitivity

T-Bet/TBX21 (D6N8B) XP^® Rabbit mAb (Alexa Fluor ® 647 Conjugate) recognizes endogenous levels of total T-Bet/TBX21 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly465 of human T-bet/TBX21 protein.

Description

This Cell Signaling Technology antibody is conjugated to Alexa Fluor^® 647 fluorescent dye and tested in-house for direct flow cytometry analysis in human cells. The antibody is expected to exhibit the same species cross-reactivity as the unconjugated T-bet/TBX21 (D6N8B) XP^® Rabbit mAb #13232.

Background

The T-box gene family consists of transcription factors characterized by a related DNA-binding domain (T-box) of approximately 200 amino acids (1,2). The T-box genes exhibit diverse temporal and spatial patterns in the developing embryo. Studies have demonstrated members of this family play crucial roles during embryogenesis in a wide range of organisms by regulating cell fate decisions to establish the early body plan and to regulate later processes underlying organogenesis (3-5). Mutations in T-box genes are associated with many developmental defects (6). Recent studies also indicate potential roles in cancer by members of T-box family (7-9).

1. Wilkinson, D.G. et al. (1990) Nature 343, 657-9.
2. Papaioannou, V.E. and Silver, L.M. (1998) Bioessays 20, 9-19.
3. Showell, C. et al. (2004) Dev Dyn 229, 201-18.
4. Papaioannou, V.E. (2001) Int Rev Cytol 207, 1-70.
5. Hoogaars, W.M. et al. (2007) Cell Mol Life Sci 64, 646-60.
6. Baldini, A. (2004) Curr Opin Cardiol 19, 201-4.
7. Abrahams, A. et al. (2010) IUBMB Life 62, 92-102.
8. Rowley, M. et al. (2004) J Mammary Gland Biol Neoplasia 9, 109-18.
9. Yang, X.R. et al. (2009) Nat Genet 41, 1176-8.

注意事项：

Storage: Supplied in PBS (pH 7.2), less than 0.1% sodium
azide and 2 mg/ml BSA. Store at 4°C. Do not aliquot the
antibody. Protect from light. Do not freeze.