Phospho-Rad50 (Ser635) Antibody

产品编号：CST-14223S 品牌：CST 原厂货号：14223S
产品分类：抗体 > 一抗 > 磷酸化抗体
应用分类：

包装：

运保温度:

–20°C.

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描述：

Specificity / Sensitivity

Phospho-Rad50 (Ser635) Antibody recognizes endogenous levels of Rad50 protein only when phosphorylated at Ser635.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser635 of human Rad50 protein. Antibodies are purified by protein A and peptide affinity chromatography.

原厂资料：

Specificity / Sensitivity

Phospho-Rad50 (Ser635) Antibody recognizes endogenous levels of Rad50 protein only when phosphorylated at Ser635.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser635 of human Rad50 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

The DNA repair protein Rad50 is a member of the structural maintenance of chromosomes family (SMC) and plays an important role in cell cycle checkpoint signaling and double-strand break repair in response to DNA damage (1-4). Rad50 forms a complex with Mre11 and Nbs1 that becomes activated in response to DNA damage (3). In normal human cells, the MRN complex acts to tether linear DNA molecules, providing a flexible link between DNA ends (1). Genomic instability and cancer have been shown to develop in cells with genetic mutations affecting the proteins in the MRN complex (2). ATM-dependent phosphorylation of Rad50 at Ser635 in response to DNA damage is important in regulating downstream signaling, DNA repair and checkpoint control (5)

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C.
Do not aliquot the antibody