Catalase (D5N7V) Rabbit mAb

• 产品编号：CST-14097S      品牌：CST       原厂货号：14097S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

Specificity / Sensitivity

Catalase (D5N7V) Rabbit mAb recognizes endogenous levels of total catalase protein. This antibody may also cross-react with an unidentified protein of approximately 35 kDa.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp128 of human catalase protein.

原厂资料：

Specificity / Sensitivity

Catalase (D5N7V) Rabbit mAb recognizes endogenous levels of total catalase protein. This antibody may also cross-react with an unidentified protein of approximately 35 kDa.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp128 of human catalase protein.

Background

Catalase catalyzes the conversion of hydrogen peroxide to water and oxygen (1). Research studies show that overexpression of this antioxidant enzyme increases the ability of pancreatic β-cells to scavenge reactive oxygen species (ROS), thereby protecting pancreatic β-cells from oxidative stress (2). The pancreatic β-cells overexpressing this enzyme are also protected from hydrogen peroxide-mediated lipotoxicity, providing further evidence for the importance of catalase in the pathogenesis of diabetes (3).

1. Chelikani, P. et al. (2004) Cell Mol Life Sci 61, 192-208.
2. Chen, H. et al. (2005) Diabetes 54, 1437-46.
3. Elsner, M. et al. (2011) Diabetes 60, 200-8.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody.