KIF3B Antibody

• 产品编号：CST-13817S      品牌：CST       原厂货号：13817S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

Specificity / Sensitivity

KIF3B Antibody recognizes endogenous levels of total KIF3B protein.

Source / Purification 

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human KIF3B protein. Antibodies are purified by protein A and peptide affinity chromatography.

原厂资料：

Specificity / Sensitivity

KIF3B Antibody recognizes endogenous levels of total KIF3B protein.

Source / Purification 

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human KIF3B protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

Kinesin superfamily proteins (KIFs) are molecular motors that drive directional, microtubule-dependent intracellular transport of membrane-bound organelles and other macromolecules (e.g. proteins, nucleic acids). The intracellular transport functions of KIFs are fundamentally important for a variety of cellular functions, including mitotic and meiotic division, motility/migration, hormone and neurotransmitter release, and differentiation (1-4). Disruptions to KIF-mediated intracellular transport have been linked with a variety of pathologies, ranging from tumorigenesis to defects in higher order brain function such as learning and memory (4-6).

KIF3B binds the related kinesin family member 3A (KIF3A) and kinesin-associated protein 3 (KAP3) to form kinesin-2, an ATP-dependent heterotrimeric motor protein complex that uses plus-end-directed microtubule sliding activity to drive anterograde organelle transport (7). Studies in the zebrafish model suggest that KIF3B is required for the development and function of cilia in multiple cell types (8). Research studies show that KIF3B protein is upregulated in human hepatocellular carcinoma and that its expression is associated with poor prognosis in this cancer type (9).

1. Hirokawa, N. et al. (2009) Nat Rev Mol Cell Biol 10, 682-96.
2. Yu, Y. and Feng, Y.M. (2010) Cancer 116, 5150-60.
3. Park, J.J. et al. (2008) Mol Endocrinol 22, 989-1005.
4. Hirokawa, N. et al. (2010) Neuron 68, 610-38.
5. Yoshimura, Y. et al. (2010) Mol Cell Biol 30, 2206-19.
6. Hirokawa, N. and Noda, Y. (2008) Physiol Rev 88, 1089-118.
7. Yamazaki, H. et al. (1995) J Cell Biol 130, 1387-99.
8. Zhao, C. et al. (2012) Proc Natl Acad Sci U S A 109, 2388-93.
9. Huang, X. et al. (2014) Dig Dis Sci 59, 795-806.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM
NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C.
Do not aliquot the antibody.