MCUR1 Antibody

• 产品编号：CST-13706S      品牌：CST       原厂货号：13706S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

Specificity / Sensitivity

MCUR1 Antibody recognizes endogenous levels of total MCUR1 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala305 of human MCUR1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

原厂资料：

Specificity / Sensitivity

MCUR1 Antibody recognizes endogenous levels of total MCUR1 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala305 of human MCUR1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

Mitochondrial Calcium Uniporter Regulator 1 (MCUR1) is a mitochondrial inner membrane protein involved in the uptake of calcium. This multi-pass protein contains two transmembrane domains with both amino- and carboxy-termini projecting into the same mitochondrial intermembrane space (1). Research studies indicate that reduction in MCUR1 activity results in decreased mitochondrial Ca²⁺ uptake, while overexpression of MCUR1 results in increased mitochondrial calcium levels (1). MCUR1 protein directly interacts with mitochondrial calcium uniporter (MCU) and plays an essential role in the regulation of calcium uptake and maintenance of mitochondrial calcium homeostasis (1). Regulation of MCU by MCUR1 may be critical for a variety of cellular functions, including signal transduction, bioenergetics, and cell death and survival (2)

1. Marchi, S. and Pinton, P. (2014) J Physiol 592, 829-39.
2. Mallilankaraman, K. et al. (2012) Nat Cell Biol 14, 1336-43.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM
NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C.
Do not aliquot the antibody.