CPEB1 Antibody

• 产品编号：CST-13583S      品牌：CST       原厂货号：13583S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

Specificity / Sensitivity

CPEB1 Antibody recognizes endogenous levels of total CPEB1 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu170 of human CPEB1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

原厂资料：

Specificity / Sensitivity

CPEB1 Antibody recognizes endogenous levels of total CPEB1 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu170 of human CPEB1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

Cytoplasmic polyadenylation element-binding protein (CPEB) is a conserved protein that binds RNA and regulates translation (1-3). CPEB binds to the cytoplasmic polyadenylation element (CPE) located in the 3′ untranslated region (UTR) of specific mRNAs expressed in germ cells, fibroblasts, and neurons (1-4). Together with other factors, CPEB promotes polyadenylation of mRNA transcripts to create mRNA poly(A) tails prior to translation (1-3). CPEB1 regulates meiotic and early-embryonic cell proliferation and is essential for mediation of poly(A) tail length changes required for mitotic cell division (4). Research studies suggest that CPEB1-mediated shortening of the 3'-UTR correlates with tumorigenesis (5).

1. Hake, L.E. and Richter, J.D. (1994) Cell 79, 617-27.
2. Mendez, R. et al. (2002) EMBO J 21, 1833-44.
3. Kim, J.H. and Richter, J.D. (2006) Mol Cell 24, 173-83.
4. Novoa, I. et al. (2010) Nat Cell Biol 12, 447-56.
5. Bava, F.A. et al. (2013) Nature 495, 121-5.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM
NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C.
Do not aliquot the antibody