Synapsin-1 (D12G5) XP??Rabbit mAb?(Alexa Fluor? 594 Conjugate)

• 产品编号：CST-13556S      品牌：CST       原厂货号：13556S
• 产品分类：抗体 > 一抗 > 染料标记抗体
• 应用分类：

描述：

Specificity / Sensitivity

Synapsin-1 (D12G5) XP^® Rabbit mAb (Alexa Fluor^® 594 Conjugate) detects endogenous levels of total synapsin protein. The antigen is 100% conserved between human synapsin-1a and synapsin-1b.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln483 of human synapsin-1 protein.

Description

This Cell Signaling Technology antibody is conjugated to Alexa Fluor^® 594 fluorescent dye and tested in-house for direct immunofluorescent analysis in mouse and rat tissue. This antibody is expected to exhibit the same species cross-reactivity as the unconjugated Synapsin-1 (D12G5) XP^® Rabbit mAb #5297.

原厂资料：

Specificity / Sensitivity

Synapsin-1 (D12G5) XP^® Rabbit mAb (Alexa Fluor^® 594 Conjugate) detects endogenous levels of total synapsin protein. The antigen is 100% conserved between human synapsin-1a and synapsin-1b.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln483 of human synapsin-1 protein.

Description

This Cell Signaling Technology antibody is conjugated to Alexa Fluor^® 594 fluorescent dye and tested in-house for direct immunofluorescent analysis in mouse and rat tissue. This antibody is expected to exhibit the same species cross-reactivity as the unconjugated Synapsin-1 (D12G5) XP^® Rabbit mAb #5297.

Background

Synapsins, a group of at least five related members (synapsins Ia, Ib, IIa, IIb, and IIIa), are abundant brain proteins essential for regulating neurotransmitter release (1,2). All synapsins contain a short amino-terminal domain that is highly conserved and phosphorylated by PKA or CaM kinase I (1). Phosphorylation of the synapsin amino-terminal domain at Ser9 inhibits its binding to phospholipids and dissociates synapsins from synaptic vesicles (2).

1. Greengard, P. (1987) Mol Neurobiol 1, 81-119.
2. Hosaka, M. et al. (1999) Neuron 24, 377-87.

注意事项：

Storage: Supplied in PBS (pH 7.2), less than 0.1% sodium
azide and 2 mg/ml BSA. Store at 4°C. Do not aliquot the anti-
body. Protect from light. Do not freeze