FABP1 (D2A3X) XP? Rabbit mAb

• 产品编号：CST-13368S      品牌：CST       原厂货号：13368S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

FABP1 (D2A3X) XP® Rabbit mAb兔单抗可以识别内源性FABP1总蛋白水平。单克隆抗体由合成肽段免疫动物产生，该肽段与人ABP1蛋白羧基末端附近氨基酸序列一致。脂肪酸结合蛋白（FABPs）结合脂肪酸和其他脂质，功能类似细胞质内的脂质伴侣（1,2）。它们参与脂肪酸和其他脂质的运输以及各种细胞的信号通路（2）。研究显示常见的肝脂肪酸结合蛋白基因FABP1在II型糖尿病和胰岛素抵抗中发挥作用（3）。

1. Tuncman, G. et al. (2006) Proc Natl Acad Sci U S A 103, 6970-5.
2. Haunerland, N.H. and Spener, F. (2004) Prog Lipid Res 43, 328-49.
3. Mansego, M.L. et al. (2012) PLoS One 7, e31853.

原厂资料：

Specificity / Sensitivity

FABP1 (D2A3X) XP^® Rabbit mAb recognizes endogenous levels of total FABP1 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human FABP1 protein.

Background

Fatty acid binding proteins (FABPs) bind to fatty acids and other lipids to function as cytoplasmic lipid chaperones (1,2). They participate in the transport of fatty acids and other lipids to various cellular pathways (2). Research studies have shown that common variants of the human liver fatty acid binding protein gene FABP1 play a role in the development of type 2 diabetes and insulin resistance (3).

1. Tuncman, G. et al. (2006) Proc Natl Acad Sci U S A 103, 6970-5.
2. Haunerland, N.H. and Spener, F. (2004) Prog Lipid Res 43, 328-49.
3. Mansego, M.L. et al. (2012) PLoS One 7, e31853.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody