Kinectin 1 (D5F7J) Rabbit mAb

• 产品编号：CST-13243S      品牌：CST       原厂货号：13243S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

</p>Kinectin 1 (D5F7J) Rabbit mAb可以识别内源性总的kinectin 1蛋白。</p>单克隆抗体由合成磷酸肽段免疫动物产生，该肽段与人kinectin 1蛋白Val186附近氨基酸一致。</p> Kinectin 1 (KTN1)是一个内质网（ER）富集的整合膜蛋白可能涉及了ER薄片的形成(reviewed in 1). Kinectin 1和微管马达蛋白kinesin结合，作为一个基于kinesin的细胞器追踪的细胞膜锚定（2）。Kinesin和kinectin1的相互作用被认为会影响ER支持的黏着斑组装（3）。Kinectin1也被认为在翻译延长过程中发挥作用，为延长因子复合物向ER锚定（4,5）。研究人员证明kinectin1的表达在多种人类病理状态下都会发生改变，包括乳腺癌（6），肝细胞癌（HCC）（7），帕金森氏病（8），以及自身免疫综合征Behçet's疾病（BD）（9,10）。

1. Lin, S. et al. (2012) Int J Biochem Cell Biol 44, 1436-43.
2. Kumar, J. et al. (1995) Science 267, 1834-7.
3. Zhang, X. et al. (2010) J Cell Sci 123, 3901-12.
4. Ong, L.L. et al. (2003) J Biol Chem 278, 32115-23.
5. Ong, L.L. et al. (2006) J Biol Chem 281, 33621-34.
6. Sutton, C.W. et al. (2010) J Proteome Res 9, 3891-902.
7. Wang, H.C. et al. (2004) Biochem Cell Biol 82, 321-7.
8. van Dijk, K.D. et al. (2012) Brain Pathol 22, 485-98.
9. Lu, Y. et al. (2005) Arthritis Res Ther 7, R1133-9.
10. Feng, X.G. et al. (2007) Clin Exp Rheumatol 25, S80-5.

原厂资料：

Specificity / Sensitivity

<p>Kinectin 1 (D5F7J) Rabbit mAb recognizes endogenous levels of total kinectin 1 protein.

Source / Purification

<p>Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val186 of human kinectin 1 protein.

Background

<p>Kinectin 1 (KTN1) is an endoplasmic reticulum (ER)-enriched integral membrane protein that may be involved in the formation of ER sheets (reviewed in 1). Kinectin 1 binds the microtubule motor protein kinesin and acts as a membrane anchor for kinesin-based organelle trafficking (2). The interaction of kinesin with kinectin 1 has been shown to affect ER-supported focal adhesion assembly (3). Kinectin 1 has also been implicated in translation elongation, as an anchor for the elongation factor complex to the ER (4,5). Research investigators have shown that kinectin 1 expression is altered in multiple human pathologies, including breast cancer (6), hepatocellular carcinoma (HCC) (7), Parkinson's disease (8), and the autoimmune syndrome Behçet's disease (BD) (9,10).

1. Lin, S. et al. (2012) Int J Biochem Cell Biol 44, 1436-43.
2. Kumar, J. et al. (1995) Science 267, 1834-7.
3. Zhang, X. et al. (2010) J Cell Sci 123, 3901-12.
4. Ong, L.L. et al. (2003) J Biol Chem 278, 32115-23.
5. Ong, L.L. et al. (2006) J Biol Chem 281, 33621-34.
6. Sutton, C.W. et al. (2010) J Proteome Res 9, 3891-902.
7. Wang, H.C. et al. (2004) Biochem Cell Biol 82, 321-7.
8. van Dijk, K.D. et al. (2012) Brain Pathol 22, 485-98.
9. Lu, Y. et al. (2005) Arthritis Res Ther 7, R1133-9.
10. Feng, X.G. et al. (2007) Clin Exp Rheumatol 25, S80-5.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody