Neurogenin 2 (D2R3D) Rabbit mAb

• 产品编号：CST-13144S      品牌：CST       原厂货号：13144S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

Neurogenin 2 (D2R3D) Rabbit mAb兔单抗可以识别内源性的neurogenin 2总蛋白。该单克隆抗体由合成的人neurogenin 2 蛋白羧基末端附近肽段免疫动物而获得。Neurogenin 2 (Ngn2, NeuroG2)是一个原神经，碱性螺旋-环-螺旋(bHLH)转录因子，也是neurogenin家族的成员，包括neurogenin 1 和neurogenin 3 (1)。Neurogenin 2在神经元祖细胞中表达，为谷氨酸能神经元生成所必需并且通常作为神经元分化的标志(2,3)。Neurogenin 2能够上调下游靶点包括bHLH转录因子NeuroD (4)。Ngn2的Tyr241磷酸化控制迁移和皮层神经元的树突形态(5)。

1. Sommer, L. et al. (1996) Mol Cell Neurosci 8, 221-41.
2. Bertrand, N. et al. (2002) Nat Rev Neurosci 3, 517-30.
3. Ma, Y.C. et al. (2008) Neuron 58, 65-77.
4. Hindley, C. et al. (2012) Development 139, 1718-23.
5. Hand, R. et al. (2005) Neuron 48, 45-62.

原厂资料：

Specificity / Sensitivity

Neurogenin 2 (D2R3D) Rabbit mAb recognizes endogenous levels of total neurogenin 2 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human neurogenin 2 protein.

Background

Neurogenin 2 (Ngn2, NeuroG2) is a proneural, basic helix-loop-helix transcription (bHLH) factor and member of the neurogenin family that includes neurogenin 1 and neurogenin 3 (1). Neurogenin 2 is expressed in neuronal progenitor cells, is required for generation of glutamatergic neurons and is commonly used as a marker of neuronal differentiation (2,3). Neurogenin 2 upregulates a number of targets including the bHLH transcription factor NeuroD (4). Phosphorylation of Ngn2 at Tyr241 controls migration and dendritic morphology of cortical neurons (5).

1. Sommer, L. et al. (1996) Mol Cell Neurosci 8, 221-41.
2. Bertrand, N. et al. (2002) Nat Rev Neurosci 3, 517-30.
3. Ma, Y.C. et al. (2008) Neuron 58, 65-77.
4. Hindley, C. et al. (2012) Development 139, 1718-23.
5. Hand, R. et al. (2005) Neuron 48, 45-62.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody.