LSm2 (D9X6C) Rabbit mAb

• 产品编号：CST-13119S      品牌：CST       原厂货号：13119S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

LSm2 (D9X6C)Antibody 能够检测内源性的 LSm2总蛋白水平。该单克隆抗体是经由合成的围绕人LSm2蛋白Gly64位点的氨基酸肽段免疫动物而生产的。LSm蛋白是一类古老的RNA结合蛋白家族的成员，他们在RNA代谢中发挥功能（1,2）。已经鉴定出了两种LSm复合物或环：LSm1-7 和LSm2-8 (1)。胞质LSm1-7复合物参与mRNA降解（3）。LSm2-8复合物是pre-tRNA和rRNA成熟所需要的（4,5），并且他们还能够与U6 snRNA 一起调控pre-mRNA的剪接（6）。最近的研究显示LSm2-8在端粒酶RNA的生物发生中发挥作用（1）。

1. Tang, W. et al. (2012) Nature 484, 260-4.
2. Wilusz, C.J. and Wilusz, J. (2005) Nat Struct Mol Biol 12, 1031-6.
3. Tharun, S. et al. (2000) Nature 404, 515-8.
4. Kufel, J. et al. (2002) Mol Cell Biol 22, 5248-56.
5. Kufel, J. et al. (2003) J Biol Chem 278, 2147-56.
6. Mayes, A.E. et al. (1999) EMBO J 18, 4321-31.

原厂资料：

Specificity / Sensitivity

LSm2 (D9X6C) Rabbit mAb recognizes endogenous levels of total LSm2 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly64 of human LSm2 protein.

Background

LSm proteins are members of an ancient family of RNA binding proteins that function in RNA metabolism (1,2). Two LSm complexes or rings have been identified based on protein composition: LSm1-7 and LSm2-8 (1). The cytoplasmic LSm1-7 complex is involved in mRNA degradation (3) while the LSm2-8 ring is required for pre-tRNA and rRNA maturation (4,5) and regulation of pre-mRNA splicing through its association with U6 snRNA (6). Recent studies show that LSm2-8 complex functions in the biogenesis of telomerase RNA (1).

1. Tang, W. et al. (2012) Nature 484, 260-4.
2. Wilusz, C.J. and Wilusz, J. (2005) Nat Struct Mol Biol 12, 1031-6.
3. Tharun, S. et al. (2000) Nature 404, 515-8.
4. Kufel, J. et al. (2002) Mol Cell Biol 22, 5248-56.
5. Kufel, J. et al. (2003) J Biol Chem 278, 2147-56.
6. Mayes, A.E. et al. (1999) EMBO J 18, 4321-31.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody