PDK1 (D4Q4D) Rabbit mAb

• 产品编号：CST-13037S      品牌：CST       原厂货号：13037S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

PDK1 (D4Q4D) Rabbit mAb兔单抗可以识别内源性总的PDK1蛋白。单克隆抗体由合成肽段免疫动物产生，该肽段与人PDK1蛋白羧基端附近氨基酸一致。磷酸肌醇依赖蛋白激酶1（PDK1）可以在多种信号传导通路中发挥作用（1,2），包括Akt和PKC同工酶p70 S6激酶和RSK的活化（3）。通过这些激酶，PDK1参与调控了广泛的生物学过程，包括细胞增殖，分化和凋亡。

1. Belham, C. et al. (1999) Curr. Biol. 9, R93-R96.
2. Toker, A. and Newton, A.C. (2000) Cell 103, 185-188.
3. Williams, M.R. et al. (2000) Curr. Biol. 10, 439-448.

原厂资料：

Specificity / Sensitivity

PDK1 (D4Q4D) Rabbit mAb recognizes endogenous levels of total PDK1 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human PDK1 protein.

Background

Phosphoinositide-dependent protein kinase 1 (PDK1) plays a central role in many signal transduction pathways (1,2) including the activation of Akt and the PKC isoenzymes p70 S6 kinase and RSK (3). Through its effects on these kinases, PDK1 is involved in the regulation of a wide variety of processes, including cell proliferation, differentiation and apoptosis.

1. Belham, C. et al. (1999) Curr. Biol. 9, R93-R96.
2. Toker, A. and Newton, A.C. (2000) Cell 103, 185-188.
3. Williams, M.R. et al. (2000) Curr. Biol. 10, 439-448.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody.