Mannose Receptor Antibody

• 产品编号：CST-12981S      品牌：CST       原厂货号：12981S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

Specificity / Sensitivity

Mannose Receptor Antibody recognizes endogenous levels of total mannose receptor protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu115 of human mannose receptor protein. Antibodies are purified by protein A and peptide affinity chromatography.

原厂资料：

Specificity / Sensitivity

Mannose Receptor Antibody recognizes endogenous levels of total mannose receptor protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu115 of human mannose receptor protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

The mannose receptor (MR/CLEC13D/CD206/MMR/MRC1/Macrophage mannose receptor 1) is an endocytic receptor expressed by populations of dendritic cells, macrophages and nonvascular endothelium (1). The mannose receptor is a heavily glycosylated type I transmembrane protein with three types of extracellular domains and a short carboxy-terminal cytoplasmic domain with no apparent signaling motif (2-4). The extracellular portion of the protein is made up of a CR domain, which binds sulfated glycans, an FNII domain, which binds collagens, and eight C-type lectin domains, which bind carbohydrates containing mannose, fucose or GlcNAc (4-7). The receptor recycles between the plasma membrane and early endosomes (8). Functions include a role in antigen cross-presentation, clearance of endogenous proteins, pathogen detection and trafficking through lymphatic vessels (9-12).

1. Martinez-Pomares, L. (2012) J Leukoc Biol 92, 1177-86.
2. Lennartz, M.R. et al. (1989) J Biol Chem 264, 2385-90.
3. Wileman, T.E. et al. (1986) Proc Natl Acad Sci U S A 83, 2501-5.
4. Taylor, M.E. et al. (1990) J Biol Chem 265, 12156-62.
5. Fiete, D.J. et al. (1998) Proc Natl Acad Sci U S A 95, 2089-93.
6. Napper, C.E. et al. (2006) Biochem J 395, 579-86.
7. Fiete, D. et al. (1997) Proc Natl Acad Sci U S A 94, 11256-61.
8. Tietze, C. et al. (1982) J Cell Biol 92, 417-24.
9. Burgdorf, S. et al. (2006) J Immunol 176, 6770-6.
10. Lee, S.J. et al. (2002) Science 295, 1898-901.
11. Milone, M.C. and Fitzgerald-Bocarsly, P. (1998) J Immunol 161, 2391-9.
12. Marttila-Ichihara, F. et al. (2008) Blood 112, 64-72.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM
NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C.
Do not aliquot the antibody.