Rab11FIP1 (D9D8P)?Rabbit mAb

• 产品编号：CST-12849S      品牌：CST       原厂货号：12849S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

Rab11FIP1 (D9D8P) Rabbit mAb兔单抗识别内源性的Rab11FIP1总蛋白。单克隆抗体由合成肽段免疫动物产生，该肽段与人Rab11FIP1蛋白Leu248邻近氨基酸序列一致。Rab11家族蛋白包括了紧密联系的Rab11a, Rab11b, 和Rab25。它们都是小GTPases被认为在调节细胞膜内吞示踪过程发挥了重要作用（1,2）。GTP结合的活化状态Rab11蛋白可以和Rab11家族相互蛋白(Rab11FIPs)通过一个保守的羧基端Rab11结合结构域结合（3,4）。至少已经发现了Rab11FIPs 的6个成员。基于序列和结构域同源性，Rab11FIP1, Rab11FIP2 和Rab11FIP5被分为class I超家族，而Rab11FIP3 和 Rab11FIP4则属于class II超家族和Arf6 和Rab11蛋白结合(5-7)。研究指出Rab11家族蛋白和它们的相互效应分子在肿瘤发生中发挥了作用（8,9）。

原厂资料：

Specificity / Sensitivity

Rab11FIP1 (D9D8P) Rabbit mAb recognizes endogenous levels of total Rab11FIP1 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu248 of human Rab11FIP1 protein.

Background

Rab11 family proteins consist of closely related Rab11a, Rab11b, and Rab25. They are small GTPases thought to play an essential role in regulating endocytic membrane traffic (1,2). The GTP-bound active state Rab11 proteins interact with the Rab11 family interacting proteins (Rab11FIPs) via a conserved carboxy-terminal Rab11-binding domain (3,4). At least six members of the Rab11FIPs have been identified. Based on sequence homology and domain structures, Rab11FIP1, Rab11FIP2 and Rab11FIP5 are categorized as class I subfamily members, whereas Rab11FIP3 and Rab11FIP4 belong to the class II subfamily that bind Arf6 and Rab11 proteins (5-7). Research studies have implicated Rab11 family proteins and their interacting effectors in carcinogenesis (8,9).

1. Bock, J.B. et al. (2001) Nature 409, 839-41.
2. Ullrich, O. et al. (1996) J Cell Biol 135, 913-24.
3. Hales, C.M. et al. (2001) J Biol Chem 276, 39067-75.
4. Prekeris, R. et al. (2001) J Biol Chem 276, 38966-70.
5. Meyers, J.M. and Prekeris, R. (2002) J Biol Chem 277, 49003-10.
6. Lindsay, A.J. and McCaffrey, M.W. (2004) J Cell Sci 117, 4365-75.
7. Hickson, G.R. et al. (2003) Mol Biol Cell 14, 2908-20.
8. Zhang, J. et al. (2009) J Clin Invest 119, 2171-83.
9. Muller, P.A. et al. (2009) Cell 139, 1327-41.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody.