XPC Antibody

• 产品编号：CST-12701S      品牌：CST       原厂货号：12701S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

多抗由合成肽段免疫动物产生，该肽段与人XPC蛋白氨基端肽段序列一致。抗体由蛋白A和肽段亲和层析技术纯化得到。核苷酸切除修复（NER）是细胞承受了化学物质或辐射暴露后识别并修复DNA损伤的过程（1）。XPC与HR23B形成复合物（2），并且由于其对扭转的DNA损伤结构的高亲和性，可以作为损伤的感受器。这个复合物定位在DNA损伤的部位募集那些起始NER的复合物（3）。XPC是八个NER蛋白（XPA-G, XPV）的其中之一，XPC发生缺陷会导致着色性干皮病，一种对日光敏感的疾病，暴露的组织易患癌症，某些情况下可能会导致神经功能受损（4）。

原厂资料：

Specificity / Sensitivity

XPC Antibody recognizes endogenous levels of total XPC protein.XPC抗体可以识别内源性XPC总蛋白。

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human XPC protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

Nucleotide excision repair (NER) is a process by which cells identify and repair DNA lesions resulting from chemical or radiation exposure (1). XPC forms a complex with HR23B (2) that acts as a damage sensor due to its high affinity for geometry distorting DNA lesions. This complex localizes to sites of DNA damage and recruits the remaining members of the preincision complex necessary for initiation of NER (3). XPC is one of eight NER proteins (XPA-G, XPV) where defects result in Xeroderma pigmentosum, a disease characterized by sunlight sensitivity, a predisposition to cancer of exposed tissue, and, in some instances, neurological defects (4).

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM
NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C.
Do not aliquot the antibody.