KIFC1 Antibody

• 产品编号：CST-12313S      品牌：CST       原厂货号：12313S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

KIFC1抗体可以识别内源性总的KIFC1蛋白。多抗由合成肽段免疫动物产生，该肽段与人KIFC1蛋白羧基端肽段序列一致。抗体由蛋白A和肽段亲和层析技术纯化得到。驱动蛋白超家族（KIFs）是一种分子马达驱动膜结合细胞器和其他大分子（例如蛋白，核酸）的方向性的，微管依赖的细胞内转运.KIFs的细胞内转运功能对于多种细胞功能是根本性的，包括有丝分裂和减数分裂，运动/迁移，激素和神经递质的释放，以及分化（1-4）。KIF-介导的胞内转运被破坏后会与一系列的病理状态相关，从肿瘤发生到高阶脑损伤，例如学习和记忆（4-6）。IFC1/HSET是一个涉及早期内吞囊泡的形成和运动的minus-end directed KIF（7,8），也涉及了微管交联和纺锤体聚集（9,10）。

1. Hirokawa, N. et al. (2009) Nat Rev Mol Cell Biol 10, 682-96.
2. Yu, Y. and Feng, Y.M. (2010) Cancer 116, 5150-60.
3. Park, J.J. et al. (2008) Mol Endocrinol 22, 989-1005.
4. Hirokawa, N. et al. (2010) Neuron 68, 610-38.
5. Yoshimura, Y. et al. (2010) Mol Cell Biol 30, 2206-19.
6. Hirokawa, N. and Noda, Y. (2008) Physiol Rev 88, 1089-118.
7. Nath, S. et al. (2007) Mol Biol Cell 18, 1839-49.
8. Zhu, C. et al. (2005) Mol Biol Cell 16, 3187-99.
9. Mountain, V. et al. (1999) J Cell Biol 147, 351-66.
10. Cai, S. et al. (2009) Mol Biol Cell 20, 1348-59.

原厂资料：

Specificity / Sensitivity

KIFC1 Antibody recognizes endogenous levels of total KIFC1 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human KIFC1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

Kinesin superfamily proteins (KIFs) are molecular motors that drive directional, microtubule-dependent intracellular transport of membrane-bound organelles and other macromolecules (e.g. proteins, nucleic acids). The intracellular transport functions of KIFs are fundamentally important for a variety of cellular functions, including mitotic and meiotic division, motility/migration, hormone and neurotransmitter release, and differentiation (1-4). Disruptions to KIF-mediated intracellular transport have been linked with a variety of pathologies, ranging from tumorigenesis to defects in higher order brain function, such as learning and memory (4-6).KIFC1/HSET is a minus-end directed KIF involved in the processing and movement of early endocytic vesicles (7,8), as well as microtubule crosslinking and spindle assembly (9,10).

1. Hirokawa, N. et al. (2009) Nat Rev Mol Cell Biol 10, 682-96.
2. Yu, Y. and Feng, Y.M. (2010) Cancer 116, 5150-60.
3. Park, J.J. et al. (2008) Mol Endocrinol 22, 989-1005.
4. Hirokawa, N. et al. (2010) Neuron 68, 610-38.
5. Yoshimura, Y. et al. (2010) Mol Cell Biol 30, 2206-19.
6. Hirokawa, N. and Noda, Y. (2008) Physiol Rev 88, 1089-118.
7. Nath, S. et al. (2007) Mol Biol Cell 18, 1839-49.
8. Zhu, C. et al. (2005) Mol Biol Cell 16, 3187-99.
9. Mountain, V. et al. (1999) J Cell Biol 147, 351-66.
10. Cai, S. et al. (2009) Mol Biol Cell 20, 1348-59.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM
NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C.
Do not aliquot the antibody.