CDX2 (D11D10) Rabbit mAb

• 产品编号：CST-12306S      品牌：CST       原厂货号：12306S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

CDX2 (D11D10)Rabbit mAb兔单抗可以识别内源性的总CDX2蛋白。此单克隆抗体由合成肽段免疫动物产生，该肽段与人CDX2蛋白的邻近氨基末端的氨基酸残基序列一致。CDX2，一种含有同源结构域的转录因子，是滋养外胚层的主要调控因子，滋养外胚层会形成哺乳动物发育时的胚外组织（1）。CDX2也涉及了小肠发育（2），过表达或表达缺失都与多种人类恶性肿瘤相关，例如Barret Esophagus（3）和结肠直肠癌（4,5）。小鼠胚胎干细胞缺乏CDX2会导致造血干细胞发育受限及Hox基因表达改变（6），指出CDX2在Hox基因调控中的作用。CDX2也被认为是人AML细胞系中Hox基因表达异常的原因（7）。

原厂资料：

Specificity / Sensitivity

CDX2 (D11D10) Rabbit mAb recognizes endogenous levels of total CDX2 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human CDX2 protein.

Background

CDX2, a homeobox domain-containing transcription factor, is a master regulator of the trophoectoderm, the layer that gives rise to extra-embryonic tissues in mammalian development (1). CDX2 is also involved in intestinal development (2), and gain of expression or loss of expression has been associated with various human malignancies such as Barret Esophagus (3) and colorectal cancer (4,5). Mouse embryonic stem cells deficient in CDX2 display limited hematopoietic progenitor development and altered Hox gene expression (6), pointing to a role for CDX2 in Hox gene regulation. CDX2 is also implicated in the aberrant expression of Hox genes in human AML cell lines (7).

1. Ralston, A. and Rossant, J. (2008) Dev Biol 313, 614-29.
2. Traber, P.G. and Silberg, D.G. (1996) Annu Rev Physiol 58, 275-97.
3. Shi, X.Y. et al. (2008) Am J Clin Pathol 129, 571-7.
4. Bakaris, S. et al. (2008) Histol Histopathol 23, 1043-7.
5. Guo, R.J. et al. (2004) Cancer Biol Ther 3, 593-601.
6. Wang, Y. et al. (2008) Proc Natl Acad Sci U S A 105, 7756-61.
7. Fröhling, S. et al. (2007) Cell Cycle 6, 2241-5.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody.