DDR2 Antibody

• 产品编号：CST-12133S      品牌：CST       原厂货号：12133S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

DDR2抗体能够检测内源性水平的总DDR2蛋白。该抗体也与未知来源的60和80 kDa蛋白发生交叉反应。该多克隆抗体是通过用合成肽免疫动物而制备的，该合成肽是人DDR2蛋白Leu491附近的残基。抗体由蛋白A和肽亲和层析法纯化。盘状结构域受体(DDRs)是一种酪氨酸激酶受体，它的胞外区有一个盘状结构同源性重复，能够被与之相结合的胞外基质胶原激活。目前已知的哺乳动物的DDRs有两种：DDR1 和DDR2 (1)。它们广泛表达于人的组织中，并有可能与平滑肌细胞介导的胶原重塑相关（2）。DDRs异常表达并激活的下游通路可能与很多和基质降解和重构增加相关的人类疾病，如心血管疾病、肝纤维化和肿瘤侵袭性疾病密切相关（1）。

1. Vogel, W. (1999) FASEB J 13 Suppl, S77-82.
2. Ferri, N. et al. (2004) Am J Pathol 164, 1575-85.
3. Badiola, I. et al. (2011) Gut , .

原厂资料：

Specificity / Sensitivity

DDR2 Antibody detects endogenous levels of total DDR2 protein. This antibody also cross-reacts with 60 and 80 kDa proteins of unknown origin.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu491 of human DDR2 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

The discoidin domain receptors (DDRs) are receptor tyrosine kinases with a discoidin homology repeat in their extracellular domains, activated by binding to extracellular matrix collagens. So far, two mammalian DDRs have been identified: DDR1 and DDR2 (1). They are widely expressed in human tissues and may have roles in smooth muscle cell-mediated collagen remodeling (2). Research studies have implicated aberrant expression and signaling of DDRs in human diseases related to increased matrix degradation and remodeling, such as cardiovascular disease, liver fibrosis, and tumor invasion (1).

1. Vogel, W. (1999) FASEB J 13 Suppl, S77-82.
2. Ferri, N. et al. (2004) Am J Pathol 164, 1575-85.
3. Badiola, I. et al. (2011) Gut , .

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM
NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C.
Do not aliquot the antibody.