ALDH1A1 (D4R9V) Rabbit mAb

• 产品编号：CST-12035S      品牌：CST       原厂货号：12035S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

ALDH1A1 (D4R9V) Rabbit mAb 兔单抗能够检测内源性的ALDH1A1总蛋白水平。单克隆抗体是由合成的小鼠源ALDH1A1蛋白C端肽段免疫动物而制备的。醛脱氢酶家族是一个大的酶家族，它们在代谢过程中将酫氧化成相应的羧酸（1）。ALDH1A1是乙醛脱氢酶在肝脏胞浆内的一种异构体，与乙醇脱氢酶一起参与酒精代谢的主要途径（2）。ALDH1A1也被称为视网膜脱氢酶1，参与视黄醇代谢，将视黄醇转换为视黄酸（3）。最近的研究表明，通过控制ALDH1A1来调控类视黄醇信号有可能会影响造血干细胞的分化（4）。最近已经将ALDH1亚型作为疾病预测的生物标志物来研究。一些研究表明ALDH1A1是一个潜在的肿瘤干细胞标记，对一些类型的肿瘤有化学抗性，如黑色素瘤（5），肺癌（6），胶质母细胞瘤（7）。

1. Jackson, B. et al. (2011) Hum Genomics 5, 283-303.
2. Edenberg, H.J. (2007) Alcohol Res Health 30, 5-13.
3. Duester, G. (2000) Eur J Biochem 267, 4315-24.
4. Chute, J.P. et al. (2006) Proc Natl Acad Sci U S A 103, 11707-12.
5. Luo, Y. et al. (2012) Stem Cells 30, 2100-13.
6. Huang, C.P. et al. (2013) Cancer Lett 328, 144-51.
7. Schäfer, A. et al. (2012) Neuro Oncol 14, 1452-64.

原厂资料：

Specificity / Sensitivity

ALDH1A1 (D4R9V) Rabbit mAb recognizes endogenous levels of total ALDH1A1 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of mouse ALDH1A1 protein.

Background

The aldehyde dehydrogenase family is a large group of enzymes that oxidize aldehydes formed through metabolic processes to their carboxylic acids (1). ALDH1A1 is a liver cytosolic isoform of acetaldehyde dehydrogenase and is involved in the major pathway of alcohol metabolism along with alcohol dehydrogenase (2). ALDH1A1 is also known as retinal dehydrogenase 1 and is involved in retinol metabolism, converting retinol to retinoic acid (3). Recent studies suggest that control of retinoid signaling through ALDH1A1 may influence hematopoietic stem cell differentiation (4). There has been recent interest in ALDH1 isoforms as predictive biomarkers in disease. Several studies have suggested that ALDH1A1 is a potential marker for cancer stem cells and chemoresistance in several tumor types, such as melanoma (5), lung cancer (6), glioblastoma (7).

1. Jackson, B. et al. (2011) Hum Genomics 5, 283-303.
2. Edenberg, H.J. (2007) Alcohol Res Health 30, 5-13.
3. Duester, G. (2000) Eur J Biochem 267, 4315-24.
4. Chute, J.P. et al. (2006) Proc Natl Acad Sci U S A 103, 11707-12.
5. Luo, Y. et al. (2012) Stem Cells 30, 2100-13.
6. Huang, C.P. et al. (2013) Cancer Lett 328, 144-51.
7. Schäfer, A. et al. (2012) Neuro Oncol 14, 1452-64.

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