NTAL/LAB (D7I2B) Rabbit mAb

• 产品编号：CST-11986S      品牌：CST       原厂货号：11986S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

NTAL/LAB (D7I2B) Rabbit mAb 能顾检测内源性水平的NTAL/LAB 总蛋白。此单克隆抗体通过合成肽免疫动物制备，这种合成肽是人源NTAL/LAB 蛋白Gly222周围的肽段。非T细胞活化连接蛋白(NTAL)/B细胞激活连接蛋白(LAB)是个小的跨膜接头蛋白，与糖脂丰富的细胞膜片段相连(1,2)。 NTAL/LAB 也被称作 LAT2 (连接活化T 细胞 2)、WBSCR5、WBS15、WBSCR15 (Williams-Beuren 综合症染色体区域15蛋白)。 NTAL/LAB在B 细胞、单核细胞、肥大细胞和自然杀伤细胞中表达, 但是在静息 T 细胞中不表达 (3)。除了激活一些受体外, NTAL/LAB 也能使酪氨酸磷酸化并招募信号分子Grb2 和 c-Cbl组成信号受体复合体(4-6)。

1. Iwaki, S. et al. (2007) Int J Biochem Cell Biol 39, 868-73.
2. Lindquist, J.A. et al. (2003) Immunol. Rev. 191, 165-182.
3. Brdicka, T. et al. (2002) J. Exp. Med. 196, 1617-1626.
4. Koonpaew, S. et al. (2004) J. Biol. Chem. 279, 11229-11235.
5. Tkaczyk, C. et al. (2004) Blood 104, 207-214.
6. Stork, B. et al. (2004) Immunity 21, 681-691.

原厂资料：

Specificity / Sensitivity

NTAL/LAB (D7I2B) Rabbit mAb recognizes endogenous levels of total NTAL/LAB protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly222 of human NTAL/LAB protein.

Background

Non-T cell activation linker (NTAL)/linker for activation of B cells (LAB) is a small transmembrane adaptor protein associated with glycolipid-enriched membrane fractions (1,2). NTAL/LAB is also known as LAT2 (linker for activation of T cells 2), WBSCR5, WBS15, and WBSCR15 (Williams-Beuren syndrome chromosome region 15 protein). It is expressed in B cells, monocytes, mast cells, and natural killer cells, but not in resting T cells (3). Upon activation of several receptors, NTAL/LAB becomes tyrosine-phosphorylated and recruits signaling molecules such as GRB2 and c-Cbl into receptor signaling complexes (4-6).

1. Iwaki, S. et al. (2007) Int J Biochem Cell Biol 39, 868-73.
2. Lindquist, J.A. et al. (2003) Immunol. Rev. 191, 165-182.
3. Brdicka, T. et al. (2002) J. Exp. Med. 196, 1617-1626.
4. Koonpaew, S. et al. (2004) J. Biol. Chem. 279, 11229-11235.
5. Tkaczyk, C. et al. (2004) Blood 104, 207-214.
6. Stork, B. et al. (2004) Immunity 21, 681-691.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody.